Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Preface Vladimir N. Uversky 1. Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis Pushpendra Mani Mishra, Navneet C Verma, Chethana Rao, Vladimir N Uversky and Chayan K Nandi 2. Transient knots in intrinsically disordered proteins and neurodegeneration Marek Cieplak, Mateusz Chwastyk, Lukasz Mioduszewski and Belisa R. H. de Aquino 3. IDPs and their complexes in GPCR and nuclear receptor signaling Myriam Guillien, Albane le Maire, Assia Mouhand, Pau Bernadó, William Bourguet, Jean-Louis Banères and Nathalie Sibille 4. Intrinsic disorder-based design of stable globular proteins Galina S. Nagibina, Tatiana N. Melnik, Ksenia A. Glukhova, Vladimir N. Uversky and Bogdan S. Melnik 5. The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation Chelsea J. Webber, Shuwen (Eric) Lei and Benjamin Wolozin 6. Context-dependent HOX transcription factor function in health and disease  Sarah E. Bondos, Gabriela Geraldo Mendes and Amanda Jons 7. Dancing while self-eating: Protein intrinsic disorder in autophagy Hana Popelka 8. Intrinsic disorder in the nickel-dependent urease network Barbara Zambelli, Luca Mazzei and Stefano Ciurli 9. Disorder and cysteines in proteins: A design for orchestration of conformational see-saw and modulatory functions Anukool A. Bhopatkar, Vladimir N. Uversky and Vijayaraghavan Rangachari

The general audience for this book includes scientists working in the fields of biochemistry, biophysics, molecular medicine, biotechnology, pharmacology and drug discovery, molecular and cellular biology, as well as students of Medical Schools, Departments of Biochemistry, Biophysics, Molecular Biology, Biotechnology, Cell Biology, etc. This book is of interest to everybody, who is fascinated by the protein intrinsic disorder phenomenon, including graduate students, postdoctoral students, and experienced researchers studying intrinsically disordered proteins (IDPs), their structures, and functions.

• Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases
• Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided
• Includes contributions from recognized experts in the field