Darwin’s Pangenesis and Its Rediscovery Part A
Advances in Genetics Series

Darwin?s Pangenesis and Its Rediscovery Part A highlights the findings of Darwin's Pangenesis, an expanded cell theory and unified theory of heredity and variation that strengthened his theory of evolution and explained many phenomena of life. Now, new advances and the discovery of circulating cell-free DNA, mobile RNAs, prions and extracellular vesicles are providing new breakthroughs, thus increasing evidence on the inheritance of acquired characters, graft hybridization, and many other phenomena that Pangenesis suggests. Sections of note in this volume include the rationale, criticisms, influence and recent molecular evidence of Darwin's Pangenesis, as well as its relation to the inheritance of acquired characters, which is often included under the blanket term "transgenerational epigenetic inheritance."

1. Darwin’s Pangenesis: A theory of everything? Yongsheng Liu 2. The criticisms of Pangenesis: The years of controversy Yongsheng Liu 3. The influence of Pangenesis on later theories Yongsheng Liu 4. In search of Darwin’s imaginary gemmules Yongsheng Liu 5. Darwin’s Pangenesis and the Lamarckian inheritance Yongsheng Liu

The scope and audience for this volume includes scholars, researchers and students of genetics, cell biology, evolutionary biology, developmental biology, agriculture, medicine and the history of science.

Professor Dhavendra Kumar is a Visiting Professor, Genomic Policy Unit, Faculty of Life Sciences and Education, The University of South Wales and Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom. He is one of the Consultants for the All Wales Medical Genetics Service and the lead Clinician for Clinical Cardiovascular Genetics. After qualifying in Medicine from the King George’s Medical College, University of Lucknow, India, he completed postgraduate training in Pediatrics with an MD. Since 1980 he has pursued a career in Medical Genetics in the UK. In 1990 he became a Diplomate of the American Board of Medical Genetics. He is a Fellow of the American College of Medical Genetics (FACMG) and as well as Royal Colleges of Physicians (FRCP-London and FRCP-Ireland) and Pediatrics and Child Health (FRCPCH-UK).

In 2015, he was conferred with the higher degree of DSc by his Alma Mater, King George’s Medical University, Lucknow (UP, India) based on his life-time contributions and achievements to genetic and genomic applications in medicine and health.

• Presents a comprehensive approach to Darwin’s Pangenesis, which is so little understood that few have recognized its far-reaching importance, but seems today surprisingly modern
• Links Darwin's hypothetical gemmules with circulating cell-free DNA, mobile RNAs, prions and extracellular vesicles, shedding new light on an old theory
• Includes section on Darwin's Pangenesis in relation to the Lamarckian inheritance of acquired characters, a central debate in the history of genetics