Heat Shock Protein 60 in Human Diseases and Disorders, 1st ed. 2019 Heat Shock Proteins Series, Vol. 18

The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health.

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

SECTION I: BIOMOLECULAR ASPECTS OF HSP60

Chapter 1. HSP60: A Story as Long as Life on the Earth

Francesco Cappello, Everly Conway de Macario and Alberto JL Macari

Department of Experimental Medicine and Clinical Neurosciences

University of Palermo

Palermo, Italy

Chapter 2. Single-Ring Intermediates in the Catalytic Cycle of the Human Mitochondrial HSP60

Jay M. Bhatt and Ricardo A. Bernal

Department of Chemistry and Biochemistry

The University of Texas at El Paso

El Paso, Texas 

Chapter 3.HSP60 Inhibitors and Modulators

Antonio Palumbo Piccionello, Paola Marzullo, Silvestre Buscemi and Andrea Pace

Dipartimento di Scienze e Tecnologie Biologiche (STEBICEF)

University of Palermo

Palermo, Italy

Chapter 4.HSP60 as Modulators of Apoptosis

Naira Rashid and Pratima Chaudhuri (Chattopadhyay)

Molecular Biophysics Lab

Amity University

Chapter 5.Utilizing The Unique Architecture And Abilities of Hsp60 In Drug Development

Tomohiro Mizobata and Yasushi Kawata

Department of Faculty of Engineering and Center for Research on Green Sustainable Chemistry

Tottori University

Chapter 6. Role of The Post-Translational Modifications of HSP60 In Disease

Department of Medicine and Surgery

University of Malta

Msida, Malta

SECTION II: HSP60 AND CANCER

Chapter 7. Evaluation of Heat Shock Protein 60 (HSP60) Chaperonin in Oncology

İsmail Ağababaoğlu

Chapter 8.Exosomal Hsp60: a Tumor Biomarker?

Stefano Fais, Mariantonia Logozzi, Giusi Alberti and Claudia Campanella

Department of Experimental Biomedicine and Clinical Neurosciences

University of Palermo

Palermo, Italy

Chapter 9.HSP60 in Cancer Immunity: Biological Basis, Diagnostic Potential and Therapeutic Opportunities

Christian R. Gomez

Department of Pathology and Radiation Oncology

University of Mississippi Medical Center

Jackson, MS

Chapter 10.Hsp60 Involvement During Carcinogenesis

Francesca Rappa, Francesco Carini and Pierre Schembri Wismayer

Department of Experimental Biomedicine and Clinical Neurosciences

University of Palermo

Palermo, Italy

Chapter 11.Anti-Human Hsp60 Autoantibodies in Autoimmune and Inflammatory Rheumatic Diseases

Georgios Efthymiou, Lazarosi Sakkas and Dimitrios P. Bogdanos

Department of Rheumatology and Clinical Immunology

University General Hospital of Larissa School of Health Sciences

University of Thessaly

Viopolis, Greece

Chapter 12.Hsp60 In Inflammatory Disorders

Antonella Marino Gammazza, Giovanni Tomasello, Angelo Leone and Abdo Jurjus

Department of Experimental Biomedicine and Clinical Neuroscience

University of Palermo

Palermo, Italy

Chapter 13.HSP60 In Atherosclerosis - Past, Present and Future

Bojana Jakic, Georg Wick and Giuseppe Cappellano

Department for Pharmacology and Genetics

Medical University of Innsbruck

Chapter 14. Cardiac Myopathy In Conditional HSP60 Transgenic Mice

Tsung-Hsien Chen, Tzu-Ying Chen, Shan-Wen Liu, Mei-Ru Chen, Yen-Ling Chen, Gin-Yen Lin, Arunim Guchaiti, Ching-Han Hsu and Kurt Ming-Lin

Institute of Biomedical Engineering and Nanomedicine

National Health Research Institutes (NHRI)

Miaoli, Taiwan

SECTION V: HSP60 AND NEUROLOGICAL AND NEUROSCIENCES

Chapter 15.Heat Shock Protein 60: An Effective Target Candidate In Neurological Diseases Treatment

Babita Sharma, Rajat Maheshwari, Ishu Khangwal, Madhu Smita and Arun Kumar Dangi

Department of Microbiology

Maharshi Dayanand University

Rohtak, Haryana, India

Chapter 16.Hsp60 In Modifications of Nervous System Homeostasis and Neurodegeneration

Celeste Caruso Bavisotto, Federica Scalia, Alessandro Pitruzzella, Magdalena Górska-Ponikowska, Claudia Marino and Giulio Taglialatela

Department of Experimental Biomedicine and Clinical Neurosciences

University of Palermo

Palermo, Italy

SECTION VI: HSP60 AND SKELETAL MUSCLE DISEASES AND DISORDERS

Chapter 17.Hsp60 in Skeletal Muscle: From Molecular Anatomy To Pathophysiology

Rosario Barone, Valentina di Felice, Dario Coletti and Alberto JL Macario

Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC)

University of Palermo

Chapter 18.Heat Shock Protein 60 (HSP60): Its Role in Skeletal Muscle Diseases and Novel Prospects for Therapy

Richa Rathor, Geetha Suryakumar, Som Nath Singh and Bhuvnesh Kumar

Department of Cellular Biochemistry

Defence Institute of Physiology and Allied Sciences (DIPAS)

Chapter 19. Heat Shock Protein 60 Regulation of Skeletal Tissue Integrity

Feng-Sheng Wang, Wei-Shiung Lian, Chung-Wen Kuo

Department of Medical Research

Kaohisung Chang Gung Memorial Hospital

SECTION VII: HSP60 IN HUMAN HEALTH

Chapter 20.Role of HSP60 In The Steroidogenesis and Reproduction

Sofia Olvera-Sanchez, Jessica Monreal-Flores, Oscar Flores-Herrera And Federico Martinez

Departamento de Bioquímica

Universidad Nacional Autónoma de México (UNAM)

Mexico City, Mexico

Chapter 21.Heat Shock Protein 60 in Skin Diseases

Papapit Tuchinda and Visith Thongboonkerd

Mahidol University

Bangkok, Thailand

Prof. Dr. Alexzander A. A. Asea is a highly innovative and accomplished world renowned clinical and basic research scientist and visionary executive leader who has exceptional experience spearheading clinical and basic science research, training, education, and commercialization initiatives within top ranked academic biomedical institutes. Prof. Dr. Asea’s initial findings studying the effects of Hsp72 on human monocytes lead to the proposal of a novel paradigm that Hsp72, previously known to be an intracellular molecular chaperones, can be found in the extracellular milieu where it has regulatory effects on immuno-competent cells - a term now called chaperokine. Prof. Asea has authored over 255 scientific publications including peer-reviewed articles, reviews, books, book chapters, editorials, and news headliners in a wide range of biomedical-related disciplines. Prof. Asea is the series editor of the widely successful book series Heat Shock Proteins (Springer Nature Publishing) and is an editorial board member of numerous scientific peer-reviewed journals. Currently, Prof. Dr. Asea is at the University of Toledo College of Medicine and Life Sciences in Toledo, USA.

Dr. Punit Kaur is an expert in onco-proteogenomics, with extensive training and experience in quantitative mass spectrometry imaging, protein chemistry and biomarker discovery. Dr. Kaur’s main research focus is on the use of heat-induced nanotechnology in combination with radiotherapy and chemotherapy in the cancer stem cell therapy. Dr. Kaur has published more than 40 scientific articles, book chapters, and reviews, and currently serves as editorial board member for the European Journal of Cancer Prevention and the Journal of Proteomics and Bioinformatics. Dr. Kaur is an editor of 9 books in the highly successful Heat Shock Proteins book series by Springer Nature Publishers. Currently, Dr. Kaur is a Visiting Scientist Professor at the University of Te

Provides the most comprehensive review of contemporary knowledge on the role of HSP60 in human diseases and disorders

Contains chapters contributed by specialists from key basic and clinical research laboratories at major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world

An important source of reference for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychology, Human Physiology, Zoology, Botany, Biotechnology, Molecular Medicine, Infectious Disease, Pathology and Pharmaceutical Sciences, as well as for researchers involved in Drug Discovery