Improving the Therapeutic Ratio in Head and Neck Cancer Cancer Sensitizing Agents for Chemotherapy Series

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic.

The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance.

This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites.

1. Overview of head and neck cancer management2. The role of immunotherapy and molecularly targeted therapies in head and neck cancer3. Targeting the PI3K/mTOR pathway4. Autophagy inhibition to sensitize HNC to radiation and chemotherapy5. Overcoming head and neck cancer stem cells6. TAM Family proteins and therapy resistance7. Eph/Ephrin family proteins and theapy resistance8. Metabolic reprogramming to modulate therapeutic sensitivity9. FGFR and cMET10. Targeting GPCRs in HNC11. Improving the response to immunotherapy12. Chk1/2 inhibition in radiation and cetuximab resistance

cancer researchers; oncologists; graduate students

Dr Bonavida has vast expertise and various reported publications in the field of tumor cell sensitization to chemotherapy (a total of greater than 500 publications) and in particular the novel role of Nitric Oxide (NO) donors in chemo-sensitization and reversal of drug resistance. In addition, he was the first scientist to co-organize an international meeting on the topic (First International Workshop on NO and Cancer, 2005).

• Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic
• Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways
• Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data