Mesenchymal Stem Cell in Veterinary Sciences, 1st ed. 2020

This book focuses on mesenchymal stem cells (MSCs) of animal origin, including their isolation, characterization, and clinical applications.

 After briefly discussing the historical development of the field of stem cell research, it describes the basic properties and nature of stem cells particularly in relation to MSCs. In turn, it reviews materials and methods used to isolate MSCs from various sources, culture expansion, characterization and long-term storage. It also explores the therapeutic efficacy, immunomodulation and anti-inflammatory, and differentiation properties of MSCs.

Importantly, the book discusses the applications of genetic engineering to enhance the efficacy and potential of MSCs in regenerative medicine. The book largely addresses the potential applications of mesenchymal stem cells in therapies for important species of domesticated animals including sheep, goats, cattle, buffalo, cats, dogs and horses. Finally, the book presents an abridgement of challenges and future prospects of stem cell research and application in medicine, in general and veterinary sciences, in particular.

Chapter1_Stem cell developmental history. -Chapter 2_Stem cell and its properties.  Chapter 3_Mesenchymal stem cell isolation, culture, characterization and cryopreservation. -Chapter 4_Mesenchymal stem cell immuno-modulation and/ anti-inflammatory properties. -Chapter 5_Mesenchymal stem cell properties and available micro-environment. -Chapter 6_ Mesenchymal stem cell genetic engineering and regenerative medicine. -Chapter 7_Sheep mesenchymal stem cell basic research and potential applications. -Chapter 8 Goat mesenchymal stem cell basic research and potential applications. -Chapter 9_Cattle/buffalo mesenchymal stem cell basic research and potential applications. -Chapter 10_Cat mesenchymal stem cell characteristics and potential applications. -Chapter 11_Dog mesenchymal stem cell basic research and potential applications. -Chapter 12_Equine mesenchymal stem cell basic research and potential applications. -Chapter 13_The future of mesenchymal stem cell research.

Dr Mudasir Bashir Gugjoo is an Assistant Professor at the Faculty of Veterinary Sciences & Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences & Technology, Kashmir, India. He has received his PhD in mesenchymal stem cell translational studies from the Indian Veterinary Research Institute, Izatnagar. He has received various awards including the Best Faculty Teacher Award. His lab focuses on the isolation and characterisation of mesenchymal stem cells and their therapeutic applications, currently being funded by Science and Engineering Research Board (SERB), Government of India. He has published more than 60 papers in various reputed peer-reviewed national and international journals, authored or co-authored a number of book chapters and is a newspaper columnist. His work has been cited in various standard books on Veterinary Medicine, Radiology and Tissue Engineering, and in numerous international research papers. He is a member of various scientific societies and serves on the editorial boards of several journals. He is also a referee for a number of peer-reviewed journals, including the Journal of Cellular Physiology, Cellular Reprogramming and Biomedicine and Pharmacotherapy, among others. 

Dr Amar Pal is currently working as a Principal Scientist & Head of the Division of Surgery at Indian Veterinary Research Institute, Izatnagar, India. He is also in-charge of the Referral Veterinary Polyclinic and the Anatomy Section at the Indian Veterinary Research Institute, Izatnagar, India. He has done pioneering research work in the areas of veterinary anaesthesia, pain management, urolithiasis, orthopaedic surgery, and stem cell biology and therapy in animals. He has developed and registered the designs of six orthopaedic devices for animals and eight veterinary mobile apps. His work has been cited in standard works on veterinary surgery, anaesthesia and pharmacology, and in countless international res

Reviews basic properties and clinical applications of mesenchymal stem cells in regenerative medicine

Summarizes methods for isolation, characterisation, and cryopreservation of MSCs

Discusses the immunomodulation and anti-inflammatory properties of MSCs

Describes the role of genetic engineering in enhancing the therapeutic capabilities of MSCs