Molecular Imaging (2^nd Ed.)
Principles and Practice

The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field.

Volume 1 Overview 1. General Principles of Molecular Imaging Brian D. Ross and Sanjiv Sam Gambhir Part I: Molecular Imaging Technologies 2. Positron Emission TomographyeMagnetic Resonance Imaging Farshad Moradi, Ryan L. Brunsing, Vipul R. Sheth and Andrei Iagaru 3. SPECT and SPECT/CT Brian F. Hutton, Marlies C. Goorden and Freek J. Beekman 4. Principles of Micro X-ray Computed Tomography Cristian T. Badea 5. Small-Animal SPECT, SPECT/CT, and SPECT/MRI Ling-Jian Meng and Neal H. Clinthorne 6. Instrumentation and Methods to Combine Small-Animal PET With Other Imaging Modalities Andrew N. Groll and Craig S. Levin 7. Functional Imaging Using Bioluminescent Reporter Genes in Living Subjects Scott K. Lyons, Kevin P. Francis and Christopher H. Contag 8. Principles and Practice of Intraoperative Fluorescence Imaging Dimitris Gorpas, Vasilis Ntziachristos and Jie Tian 9. Molecular Endoscopic Imaging in Cancer Timo Rath, Markus F. Neurath and Raja Atreya 10. Intravital Microscopy Shariq M. Usmani and Thorsten R. Mempel 11. Ultrasound F. Stuart Foster and Emmanuel Cherin 12. Hybrid PET-CT-Ultrasound Imaging Bertrand Tavitian and Mailyn Perez-Liva 13. Photoacoustic Molecular Imaging: Principles and Practice Junjie Yao and Lihong V. Wang 14. Inhaled Gas Magnetic Resonance Imaging: Advances, Applications, Limitations, and New Frontiers Alexander M. Matheson, Caleb Thompson and Grace Parraga 15. Magnetic Particle Imaging for Vascular, Cellular and Molecular Imaging Prashant Chandrasekharan, Zhi Wei Tay, Xinyi Y. Zhou, Elaine Y. Yu, Barry K.L. Fung, Caylin Colson, Benjamin D. Fellows, Yao Lu, Quincy Huynh, Chinmoy Saayujya, Paul Keselman, Daniel Hensley, Kuan Lu, Ryan Orendorff, Justin Konkle, Emine Ulku Saritas, Bo Zheng, Patrick Goodwill and Steven Conolly 16. Optogenetics Maria G. Paez Segala and Loren L. Looger 17. Imaging Mass Spectrometry Richard R. Drake, Danielle A. Scott and Peggi M. Angel 18. CEST (Chemical Exchange Saturation Transfer) MR Molecular Imaging Guanshu Liu and Peter C.M. van Zijl 19. Molecular Imaging Using Raman Scattering Stefan Harmsen and Sanjiv Sam Gambhir 20. Synchrotron-Based Dynamic Lung Imaging Stephen Dubsky 21. Light-Sheet Fluorescence Microscopy for Multiscale Biological Imaging Jae-Byum Chang, Ruixuan Gao and Fei Chen 22. Cerenkov Imaging Edwin C. Pratt, Ryo Tamura and Jan Grimm 23. Near-Infrared II Optical Imaging Shuqing He and Zhen Cheng Part II: Chemistry of Molecular Imaging 24. Chemistry of Molecular Imaging: An Overview Silvio Aime, Fabio Travagin, Enzo Terreno and Giovanni B. Giovenzana 25. PET Radiochemistry Henry F. VanBrocklin 26. SPECT Radiochemistry Theodosia Maina and Mathew Thakur 27. The Chemistry in Surface Functionalization of Nanoparticles for Molecular Imaging 493 Xianchuang Zheng, Joanna Wang and Jianghong Rao 28. Newer Bioconjugation Methods Ahmet Krasniqi, Catarina Xavier and Nick Devoogdt 29. Targeted Antibodies and Peptides Michael R. Lewis, Cathy S. Cutler and Silvia S. Jurisson 30. Antibody-Based Molecular Imaging Kathryn M. Tully, Veronica L. Nagle, Joshua A. Korsen and Jason S. Lewis 31. Hyperpolarized Magnetic Resonance With Dissolution Dynamic Nuclear Polarization: Principles and Applications Jan H. Ardenkjaer-Larsen 32. Magnetic Resonance Imaging Agents Cuihua Wang, Elisenda Rodriguez and John W. Chen 33. Optical Imaging Agents Luisa Ottobrini, Cristina Martelli and Giovanni Lucignani 34. Photoacoustic Molecular Imaging With Exogenous Agents Liming Nie, Yajing Liu and Xiaogyuan Chen 35. Ultrasound Contrast Agents Mark A. Borden, Paul A. Dayton, Connor Slagle and Rachel W. Walmer 36. Theranostics: Agents for Diagnosis and Therapy Fay Nicolson and Moritz F. Kircher 37. Magnetic Nanoparticles Ahmad Amirshaghaghi, Zhiliang Cheng, Lee Josephson and Andrew Tsourkas 38. Aptamers for Molecular Imaging Fre´de´ric Duconge´ 39. Nonclinical Product Developmental Strategies, Safety Considerations and Toxicity Profiles of Medical Imaging and Radiopharmaceuticals Products Adebayo Laniyonu, Yanli Ouyang, Jonathan Cohen, Sunny Awe, Olayinka Dina, Siham Biade, Sally Hargus and Tushar Kokate 40. Intraoperative Molecular Imaging Agents Stan van Keulen and Eben L. Rosenthal

Volume 2 Part III: Molecular Imaging in Cell and Molecular Biology 41. Protein Engineering for Molecular Imaging Anna M. Wu 42. Phage Display for Imaging Agent Development Jessica Hung, Fred Reynolds and Kimberly A. Kelly 43. Molecular Imaging of Gene Therapy Ramasamy Paulmurugan and Tarik F. Massoud 44. Cell Surveillance Using Magnetic Resonance Imaging Brooke M. Helfer and Jeff W.M. Bulte 45. Tumor Vasculature Susan Notohamiprodjo, Zohreh Varasteh, Ambros J. Beer, Gang Niu, Xiaoyuan (Shawn) Chen, Wolfgang Weber and Markus Schwaiger 46. Imaging Hypoxia Hong Yuan, Gregory M. Palmer and Mark W. Dewhirst 47. Molecular Imaging of ProteineProtein Interactions and Protein Folding Tarik F. Massoud and Ramasamy Paulmurugan 48. Molecular Imaging of Cellular Signaling Pathways Kathryn E. Luker 49. Exosome Imaging Do Won Hwang, Minseok Suh and Dong Soo Lee 50. Gene-Editing Technologies and Applications for Molecular Imaging Gary D. Luker 51. Reporter Genes for Ultrasound and MRI Mikhail G. Shapiro 52. Theranostic Approaches Using Live Bacteria Jung-Joon Min, Mai Thi-Quynh Duong, Thangam Ramar, Sung-Hwan You and Sae-Ryung Kang Part IV: Applications of Molecular Imaging Oncology 53. Molecular and Functional Imaging and Theranostics of the Tumor Microenvironment Marie-France Penet, Samata Kakkad, Jesus Pacheco-Torres, Santosh Bharti, Balaji Krishnamachary and Zaver M. Bhujwalla 54. Novel Magnetic Resonance Imaging and Positron Emission Tomography in the RT Planning and Assessment of Response of Malignant Gliomas David Kamson and Christina Tsien 55. PET Diagnosis and Response Monitoring in Oncology Richard L. Wahl and Rodney J. Hicks 56. Spectroscopic MRI for Brain Tumor Imaging Hyunsuk Shim 57. Cancer Detection and Quantification of Treatment Response Using Diffusion-Weighted MRI Brian D. Ross and Thomas L. Chenevert 58. Prostate Cancer Theranostics Steven P. Rowe, Mohammad S. Sadaghiani, Rudolf A. Werner, Takahiro Higuchi, Thorsten Derlin, Lilja B. Solnes and Martin G. Pomper 59. Pediatric Molecular Imaging Heike E. Daldrup-Link Cardiovascular 60. Imaging Myocardial Metabolism Robert J. Gropler 61. Congestive Heart Failure Stephan G. Nekolla, Antti Saraste, Hendrik Sager, Marcus R. Makowski and Markus Schwaiger 62. Molecular Imaging of Atherosclerosis Eric A. Osborn, Mazen Albaghdadi, Peter Libby and Farouc A. Jaffer 63. Thrombosis and Embolism Reza Hajhosseiny, Claudia Prieto, Haikun Qi, Alkystis Phinikaridou and Rene´ M. Botnar 64. Molecular Imaging of Stem Cell Therapy in Ischemic Cardiomyopathy Mark Chandy and Joseph C. Wu Central Nervous System 65. Central Nervous System Molecular Imaging Lilja B. Solnes, Andreas H. Jacobs, Jennifer M. Coughlin, Yong Du, Reema Goel, Dima A. Hammoud and Martin G. Pomper 66. Applications, Advances, and Limitations of Molecular Imaging of Brain Receptors Paul Cumming, Gerhard Gru¨nder, Zabecca Brinson and Dean F. Wong 67. PET and SPECT Imaging of Neurodegenerative Diseases Alexander Drzezga, Ge´rard N. Bischof, Kathrin Giehl and Thilo van Eimeren 68. PET Imaging of Neuroinflammation Aisling M. Chaney, Emily M. Deal, Isaac M. Jackson and Michelle L. James Autoimmunity and Immunology 69. Identifying Musculoskeletal Pain Generators Using Molecular Imaging Daehyun Yoon, Feliks Kogan, Garry Gold and Sandip Biswal 70. Molecular Imaging of Autoimmune Diseases Alberto Signore, Arianna Di Paolo and Filippo Galli 71. Molecular Imaging of Diabetes Lieke Joosten, Marti Boss, Tom Jansen, Maarten Brom, Mijke Buitinga, Erik Aarntzen, Olof Eriksson, Lars Johansson, Bastiaan de Galan and Martin Gotthardt 72. Imaging in Asthma Avanti Gulhane and Delphine L. Chen 73. Molecular Imaging of Fibrosis Iris Y. Zhou, Sydney B. Montesi, Eman A. Akam and Peter Caravan 74. Imaging of Bacterial Infections Alvaro A. Ordon˜ez and Sanjay K. Jain Part V: Molecular Imaging in Drug Evaluation 75. Molecular and Functional Imaging in Central Nervous System Drug Development Basil Ku¨nnecke, Michael Honer, Gennaro Pagano and Markus Rudin 76. PET Imaging in Cancer Clinical Trials David A. Mankoff 77. Magnetic Resonance Imaging: Cardiovascular Applications for Clinical Trials Chun Yuan, Zach Miller and Xue-Qiao Zhao 78. Imaging of Gene and Cell-Based Therapies: Basis and Clinical Trials Andreas H. Jacobs, Sonja Schelhaas, Thomas Viel, Yannic Waerzeggers, Alexandra Winkeler, Bastian Zinnhardt and Juri Gelovani Part VI: Image Quantitation/Analytics 79. Virtual and Augmented Reality Technologies in Molecular and Anatomical Imaging Suman B. Mondal and Samuel Achilefu 80. Quantification of Radiotracer Uptake Into Tissue Michael M. Graham 81. Pharmacokinetic Modeling Sung-Cheng (Henry) Huang 82. Online Social Media: Concepts and Practices for Molecular Imaging Professionals Chadwick L. Wright, Michelle I. Knopp and Michael V. Knopp 83. The Regulatory Process for Imaging Agents and Devices Matthew F. Covington, Sally W. Schwarz and John M. Hoffman 84. Operational Radiation Safety for PET-CT, SPECT-CT, and Cyclotron Facilities Pat Zanzonico 85. Bridging Spatial Scales From Radiographic Images to Cellular and Molecular Properties in Cancers Natarajan Raghunand and Robert A. Gatenby 86. AI/Machine Learning in Medical Imaging Maryellen L. Giger 87. Retrospective Registration in Molecular Imaging Brian D. Ross, Thomas L. Chenevert and Charles R. Meyer 88. Image Processing Analytics: Enhancements and Segmentation Lubomir Hadjiiski, Ravi Samala and Heang-Ping Chan 89. Magnetic Resonance Fingerprinting: Basic Concepts and Applications in Molecular Imaging Kathleen Ropella-Panagis and Nicole Seiberlich 90. MR Elastography Patrick J. Navin, Sudhakar Kundapur Venkatesh and Richard L. Ehman

• The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data
• Concepts illustrated with over 600 color figures and molecular-imaging examples
• Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development
• This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications
• Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented
• This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications