Principles of Molecular Medicine (2^nd Ed., 2nd ed. 2006)

The concept of molecular medicine dates back to Linus means that there are many new opportunities and challenges Pauling, who in the late 1940s and early 1950s generalized for clinical medicine. One of the effects of the completion of from the ideas that came from the study of the sickle cell the Human Genome Project is the increasing application of hemoglobin molecule. With the first cloning of human genes the fields of molecular biology and genetics to the und- about 1976, molecular genetics took the molecular perspec- standing and management of common diseases. Assimi- tive on disease to the level of DNA. The term molecular tion of the new developments since the first edition has been medicine achieved wide currency in the 1980s with the ably accomplished by Drs. Runge and Patterson with the assignment of this designation to journals, at least one soci- help of their many knowledgeable authors. ety, institutes, and academic divisions of departments of in- As was evident in the firstedition, molecular genetics is ternal medicine. Undoubtedly, molecular medicine has been involved in every specialty of medicine. A recurrent theme abetted by the Human Genome Project, which has aided in that edition, perhaps even more striking in the present one, greatly in the molecular characterization of disease.

Genetics.- Mendelian Inheritance.- Nontraditional Inheritance.- Identifying Causal Genetic Factors.- Cancer Genetics and Molecular Oncology.- Pharmacogenetics.- Hemophilia as a Model Disease for Gene Therapy of Genetic Disorders.- Genetic Counseling.- Animal Models in Biomedical Research.- Ethical, Legal, and Social Implications.- Cardiology.- Congenital Heart Disease.- Inherited Cardiomyopathies.- Heart Failure.- Aortic Diseases.- Atherosclerotic Coronary Disease.- Lipid Metabolism and Coronary Artery Disease.- Hypertension.- Cardiac Hypertrophy.- Arrhythmias.- Genomics.- Cardiovascular Gene Therapy.- Pulmonary Diseases.- Idiopathic Interstitial Pneumonias.- Asthma.- Pulmonary Emphysema.- Pulmonary Hypertension.- Acute Lung Injury.- Primary Ciliary Dyskinesia.- Cystic Fibrosis.- Gene Therapy for Lung Diseases.- Sarcoidosis.- Disorders of Pulmonary Surfactant Homeostasis.- Endocrinology.- Mechanisms of Hormone Action.- Diabetes Mellitus.- Pituitary Function and Neoplasia.- Growth Hormone Deficiency Disorders.- Thyroid Disorders.- Disorders of the Parathyroid Gland.- Congenital Adrenal Hyperplasia.- Adrenal Diseases.- Multiple Endocrine Neoplasia Type 1.- Multiple Endocrine Neoplasia Type 2.- Disorders of Sex Determination and Differentiation.- Sex Chromosome Disorders.- Disorders of Pubertal Development.- Defects of Androgen Action.- Molecular Endocrinology of the Testis.- Ovarian Diseases.- Metabolic Disorders.- Gastrointestinal Regulation of Food Intake.- Cellular Regulation of Lipolysis.- Fat-Induced Insulin Resistance and Atherosclerosis.- Metabolic and Molecular Aspects of Sarcopenia.- Adipose Tissue Development and Metabolism.- Gastroenterology.- Hepatitis C.- Molecular Diagnostics in Hepatitis B.- Hereditary Hemochromatosis.- Pancreatic Exocrine Dysfunction.- Small and Large Bowel Dysfunction.- The Molecular Mechanisms of Helicobacter pylori-Associated Gastroduodenal Disease.- Nephrology.- Nitric Oxide Synthase and Cyclooxygenase in the Kidneys.- Hypertensionand Sodium Channel Turnover.- Nephrogenic Diabetes Insipidus st[Water and Urea Transport.- Glomerulonephritis and Smad Signaling.- Interstitial Nephritis.- The Pathophysiology of Acute Renal Failure.- Loss of Lean Body Mass in Uremia.- Mechanisms of Renal Allograft Rejection.- Musculoskeletal.- Muscle Development and Differentiation.- Skeletal Muscle Structure and Function.- Stem Cells and Muscle Regeneration.- Skeletal Muscle Hypertrophy and Response to Training.- Muscular Dystrophies.- Rhabdomyosarcomas.- Oncology.- Apoptosis.- Colorectal Cancer.- Breast Cancer.- Lung Cancer.- Discoveries and Frontiers in Prostate Cancer Translational Sciences.- Cutaneous Melanoma.- Applications of Gene Expression Profiling to the Study of Malignant Gliomas.- Acute Myeloid Leukemias.- Acute Lymphoblastic Leukemia.- Chronic Myelogenous Leukemia.- Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia.- Multiple Myeloma.- HIV-1, AIDS, and Related Malignancies.- Hematology.- Disorders of the Red CellMembrane.- Paroxysmal Nocturnal Hemoglobinuria.- Iron Metabolism.- Correction of Genetic Blood Defects by Gene Transfer.- Bone Marrow Failure Syndromes.- Coagulation Disorders.- Advances in Transfusion Safety.- Immunology And Infectious Diseases.- Immunomodulation.- HIV Molecular Biology, Treatment Resistance.- Cellular and Molecular Aspects of Pneumonia.- Molecular Pathogenesis of Fungal Infections.- Dermatology.- Psoriasis.- Atopic Dermatitis.- Pemphigus Foliaceus, Pemphigus Vulgaris, Paraneoplastic Pemphigus, Bullous Pemphigoid, Herpes Gestationis, and Cicatricial Pemphigoid.- Systemic Lupus Erythematosus.- Systemic Sclerosis.- Diseases With Signaling and Transcriptional Abnormalities.- Genetic Skin Diseases With Neoplasia.- Melanoma and Nevi.- Disorders of Hypopigmentation.- Epidermolysis Bullosa.- Connective Tissue Disorders.- Genetic Epidermal Diseases.- Genetic Hair and Nail Defects.- Metabolic Genetic DisordersWith Prominent Skin Findings.- Heritable Conditions Affecting Tissues of the Oral Cavity.- Neurology.- The Genetic Basis of Human Cerebral Cortical Malformations.- Muscular Dystrophies.- Channelopathies of the Nervous System.- Charcot-Marie-Tooth Disease and Related Peripheral Neuropathies.- Amyotrophic Lateral Sclerosis and Related Motor Neuron Disorders.- Trinucleotide Repeat Disorders.- Parkinson’s Disease.- Genetics and Neurobiology of Alzheimer’s Disease and Frontotemporal Dementias.- Prion Diseases.- Narcolepsy and Other Neurological Sleep Disorders.- Neurofibromatosis 1 and 2.- Axonal Regeneration and Recovery From Chronic Central Nervous System Injury.- Psychiatry.- Molecular Mechanisms Regulating Behavior.- The Complex Genetics of Psychiatric Disorders.- Treating Depression.- Anxiety Disorders.- Trauma Spectrum Disorders.- Schizophrenia.- Disorders of Substance Abuse and Dependence.- Autism and Related Disorders.

Includes supplementary material: sn.pub/extras