Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A

Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems, Part A presents a collation of chapters written by global, eminent scientists. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. Chapters in this release include An Introduction and applications of CRISPR-Cas Systems, History, evolution and classification of CRISPR-Cas associated systems, CRISPR based bacterial genome editing and removal of pathogens, CRISPR based genome editing and removal of human viruses, CRISPR based development of RNA editing and diagnostic platform, and much more.

Additional sections cover Genome engineering in insects for control of vector borne diseases, Development of insect cell line using CRISPR technology, CRISPRing protozoan parasites to better understand the biology of diseases, CRISPR based genome editing of Caenorhabditis elegans, and a variety of other important topics.

1. An introduction and use of the CRISPR-Cas systems Vijai Singh

2. History, evolution and classification of CRISPR-Cas associated systems Nisheeth Agarwal and Radhika Gupta

3. CRISPR based bacterial genome editing and removal of pathogens Ravi Jothi, Chandrasekar Karthika, Arumugam Kamaladevi, Lakkakula Satish, Shunmugiah Karutha Pandian and Shanmugaraj Gowrishankar

4. CRISPR based genome editing and removal of human viruses Yuan-Chuan Chen

5. CRISPR based development of RNA editing and the diagnostic platform Lakkakula Satish, Gunamalai Lavanya, Thirupathi Kasthuri, Aruchamy Kalaivaani, Sasanala Shamili, Muthuramalingam Pandian, Shanmugaraj Gowrishankar, Shunmugiah Karutha Pandian, Vijai Singh, Yaron Sitrit and Ariel Kushmaro

6. CRISPR-based pathogenic fungal genome editing for control of infection and disease Takayuki Arazoe

7. Genome engineering in insects for the control of vector borne diseases V. Edwin Hillary and S. Antony Ceasar

This book will be valuable sources of information for not only beginner in area of genome engineering area, but also researchers, students, scientists, clinicians, stakeholders, policy makers and practitioners and many more.

• Offers a basic understanding and clear picture of genome editing CRISPR-Cas systems in different organisms
• Explains how to create an animal model for disease diagnosis/research and reprogram CRISPR for removal of virus, bacteria, fungi, protozoan, and many more
• Discusses the advances, patents, applications, challenges and opportunities in CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, and many more