Description
Research in the Biomedical Sciences
Transparent and Reproducible
Coordinators: Williams Michael, Curtis Michael, Mullane Kevin
Language: English
Subjects for Research in the Biomedical Sciences:
Keywords
animal models; biomedical research culture; data analysis; drug discovery; drug prices; exploratory data analysis; fraud; guidelines; checklists; healthcare; hypothesis generation; hypothesis testing; inference; investigator bias; journal impact factor; manuscript preparation; peer review; power; randomization; reagent validation/authentication; reproducibility; reproducibility initiatives; statistics; translational research
Support: Print on demand
Description
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Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting.
The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved.
This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences.
1. Reproducibility in Biomedical Research 2. Experimental Planning and Execution 3. Statistical Analysis in Preclinical Biomedical Research 4. Reporting Results 5. Addressing Reproducibility: Peer Review, Checklists, Guidelines and Reproducibility Initiatives 6. Issues in Contemporary Biomedical Research
Graduate students in biomedical research fields including pharmacology, pharmaceutical science, molecular biology, systems biology and more and early career researchers in academia and the pharmaceutical industry
Michael Curtis is a Reader in Pharmacology, King’s College London, Rayne Institute, St. Thomas’ Hospital, London, UK
Kevin Mullane is Director, Corporate Liaison and Ventures with J. David Gladstone Institutes, University of California, San Francisco in San Francisco, CA
- Provides a “big picture perspective on the scope of reproducibility issues and covers initiatives that have potential as effective solutions
- Offers real-world research context for transparent, reproducible experimental design, execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery
- Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability
