Single-molecule Studies of Proteins, 2013
Biophysics for the Life Sciences Series, Vol. 2

Coordinator: Oberhauser Andres F.

Language: English
Cover of the book Single-molecule Studies of Proteins

Subject for Single-molecule Studies of Proteins

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274 p. · 15.5x23.5 cm · Paperback
In Single Molecule Studies of Proteins, expert researchers discuss the successful application of single-molecule techniques to a wide range of biological events, such as the imaging and mapping of cell surface receptors, the analysis of the unfolding and folding pathways of single proteins, the analysis interaction forces between biomolecules, the study of enzyme catalysis or the visualization of molecular motors in action. The chapters are aimed at established investigators and post-doctoral researchers in the life sciences wanting to pursue research in the various areas in which single-molecule approaches are important; this volume also remains accessible to advanced graduate students seeking similar research goals.

Chapter 1: Nanomechanics of proteins, both folded and disordered 
Rubén Hervás, Albert Galera-Prat, Àngel Gómez-Sicilia, Fernando Losada-Urzáiz, María del Carmen Fernández, Débora Fernández-Bravo, Elena Santana, Clara Barrio-García, Carolina Melero & Mariano Carrión-Vázquez

Chapter 2: Force Spectroscopy and Recognition Imaging of Cells from the Immune System   
Bianca L Bozna
Memed Duman
Peter Hinterdorfer

Chapter 3: Catch bonds of integrin/ligand interactions 
Cheng Zhu
Wei Chen

Chapter 4: AFM visualization of protein-DNA interactions 
Yuri L Lyubchenko

Chapter 5: Nano-visualization of proteins in action using high-speed AFM 
Takayuki Uchihashi
Noriyuki Kodera
Toshio Ando

Chapter 6: Enzyme catalysis at the single-molecule level 
Raul Perez Jimenez
Jorge Alegre-Cebollada

Chapter 7: Single-molecule studies of amyloidogenic proteins 
Miklós S.Z. Kellermayer
Árpád Karsai
Ünige Murvai
Szilvia Erdélyi-Bótor
József Kardos
Ricardo H. Pires

Chapter 8: Stretching and Imaging Individual Proteins on Live Cells using Atomic Force Microscopy 
David Alsteens
Yves Dufrêne

Chapter 9: Individual proteins under mechanical stress: Lessons from theory and computer simulations 
Dmitrii E Makarov

Explores sophisticated advances in powerful new analytical, computational, and imaging methods

Cover ways in which single-molecule methods can be applied to studying protein function

Lays the foundation for additional research to monitor processes within living cells at high resolution and define the complex networks of interactions which regulate cellular function

Includes supplementary material: sn.pub/extras