Therapeutic Antibodies, 2008
Handbook of Experimental Pharmacology Series, Vol. 181

Coordinators: Chernajovsky Yuti, Nissim Ahuva

Language: English

Approximative price 316.49 €

In Print (Delivery period: 15 days).

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Therapeutic Antibodies
Publication date:
380 p. · 15.5x23.5 cm · Paperback

Approximative price 316.49 €

Subject to availability at the publisher.

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Therapeutic antibodies
Publication date:
380 p. · 15.5x23.5 cm · Hardback

This essential work, edited by two researchers at London?s famous Queen Mary?s medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes.

Historical Development of Monoclonal Antibody Therapeutics.- Preclinical Safety Evaluation of Monoclonal Antibodies.- Molecular Developments in Antibody Production.- Engineering Antibodies for Stability and Efficient Folding.- Human Monoclonal Antibodies from Transgenic Mice.- Antibodies to Cytokines.- Anti-TNF Antibodies: Lessons from the Past, Roadmap for the Future.- Therapeutic Anti-VEGF Antibodies.- Humanized Antihuman IL-6 Receptor Antibody, Tocilizumab.- Antibodies to Cell Markers.- Anti-CD20Monoclonal Antibody in Rheumatoid Arthritis and Systemic Lupus Erythematosus.- Herceptin.- The Use of CD3-Specific Antibodies in Autoimmune Diabetes: A Step Toward the Induction of Immune Tolerance in the Clinic.- Monoclonal Antibody Therapy for Prostate Cancer.- Anti-IgE and Other Antibody Targets in Asthma.- Development of Antibody-Based Cellular and Molecular Therapies.- Cytokine, Chemokine, and Co-Stimulatory Fusion Proteins for the Immunotherapy of Solid Tumors.- The T-Body Approach: Redirecting T Cells with Antibody Specificity.- Intracellular Antibodies (Intrabodies) and Their Therapeutic Potential.

Includes supplementary material: sn.pub/extras