Upscaling of Bio-Nano-Processes, 2014
Selective Bioseparation by Magnetic Particles
Lecture Notes in Bioengineering Series

Despite ongoing progress in nano- and biomaterial sciences, large scale bioprocessing of nanoparticles remains a great challenge, especially because of the difficulties in removing unwanted elements during processing in food, pharmaceutical and feed industry at production level. This book presents magnetic nanoparticles and a novel technology for the upscaling of protein separation. The results come from the EU Project "MagPro2Life", which was conducted in cooperation of several european institutions and companies.

Introduction.- Part I: Particle Synthesis and Functionalization.- New Advances in the Production of Iron-Based Nanostructures by Laser Pyrolysis.- Chemical Coprecipitation for Hydrophobic and Hydrophilic Magnetite Nanoparticles.- Magnetic Microgels: Synthesis and Characterization.- Vesicles and Composite Particles by Rotating Membrane Pore Extrusion.- Synthesis of Functionalized Magnetic Beads Using Spray Drying.- Industrial Production, Surface Modification and Application of Magnetic Particles.- Part II: Magnetic Separation Devices.- Magneticall Enhanced Centrifugation for Industrial Use.- Design and Performance of a Pilot Scale High-Gradient Magnetic Filter using a Mandhala Magnet and its Application for Soy-Whey Protein Purification.- Continuous Magnetic Extraction for Protein Purification.- Part III: Process examples.- In-situ Magnetic Separation of Pilot Scale : A Tool for Process Optimization.- An Industrial Approach to High-Gradient Magnetic Filtration in the Food Industry.- Conclusion.

Prof. Dr.-Ing. Hermann Nirschl is head of chair of process machinery at the institute of mechanical process engineering and mechanics at the Karlsruhe Institute of Technology, focusing on process machinery in solid liquid separation, blending, milling, nanoscaled particle structures and numerical simulation.

Dr. KarstenKeller is an Engineering Fellow of the Discovery Research group at Solae LLC (JV of DuPont) and has over 20 years of process engineering experience. He is developing novel processes for protein and new product opportunities from the lab-scale to commercial production and is the author of over 70 publications on subjects of separation, modeling, particle technology, biotechnology and nanotechnology. He is the inventor of 8 patents worldwide.