Description
Using Mass Spectrometry for Drug Metabolism Studies (2nd Ed.)
Coordinator: Korfmacher Walter A.
Language: EnglishSubjects for Using Mass Spectrometry for Drug Metabolism Studies:
Keywords
Sample Preparation; ADME Study; Mass Spectrometry; Mass Spectrometric; MALDI IMS; Reactive Metabolites; GSH Adduct; Mass Analyzer; MS System; IMS; Ion Trap; AMS Analysis; Full Scan MS; Pro Ling; Triple Quadrupole Mass Spectrometers; Matrix Effects; Ef Cacy; Conventional LC MS; Ambient Ionization Mass Spectrometry; Dose Normalize AUC; MALDI MS Imaging; Plasma Concentration; MALDI MS; CYP Inhibition; Matrix Ion Suppression
Publication date: 10-2019
· 15.6x23.4 cm · Paperback
Publication date: 11-2009
430 p. · 15.6x23.4 cm · Hardback
Description
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The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices.
The stand-alone chapters cover various topics ? from metabolite identification to fast chromatography with UPLC ? and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART.
With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.
Strategies and Techniques for Bioanalytical Assays as Part of New Drug Discovery. The Drug Discovery Process: From Molecules to Drugs. PK Principles and PK/PD Applications. Mass Spectrometry for In Vitro ADME Screening. Metabolite Identification Strategies and Procedures. Reactive Metabolite Screening and Covalent-Binding Assays. Fast Metabolite Screening in a Discovery Setting. Fast Chromatography with UPLC and Other Techniques. Supercritical Fluid Chromatography–Mass Spectrometry. Biomarkers of Efficacy and Toxicity: Discovery and Assay. Imaging Mass Spectrometry for Small Molecules. MALDI IMS for Proteins and Biomarkers. Ambient Ionization Methods and Their Early Applications in ADME Studies. Pharmaceutical Applications of Accelerator Mass Spectrometry.