Acetaminophen Toxicity
Experimental and Clinical Advances

Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity. Divided into two parts, the foundational aspects of the book cover the mechanism of toxicity in a detailed manner, beginning with the history of acetaminophen and then delving into newly explored areas of genetics, proteomics, and metabolomics. The second half discusses clinical practices and examines where further research and therapeutic approaches may be headed. This part answers key questions about who to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments. With contributions from experts in the field, the book is a thorough, well-researched, and a valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with of acetaminophen toxicity.

Part 1: Foundational Aspects 1. History of Acetaminophen 2. Intracellular Signaling Mechanisms of Cell Death. 3. Mode of Cell Death 4. Inflammation 5. Regeneration 6. Biomarkers 7. Emerging Mechanisms 8. Renal Toxicity 9. Pulmonary Toxicity 10. Genomics, Proteomics and Metabolomics Part II: Clinical and Therapeutic 11. N-Acetylcysteine (NAC) 12. Adducts 13. Pre-Hospital and Poison Center Care of Overdose and Potential Overdoses Patients 14. Acetaminophen and Co-Ingestions 15. Current Standard of Care and New Developments 16. Pharmacokinetics 17. Risk Analysis and Acetylcysteine Treatment Protocols 18. Fomepizole 19. Epidemiology NPDS (Poison Center Data) CDC and Other Databases 20. Emerging Treatments 21. Liver Transplantation

Dr. Barry H. Rumack, MD is currently Professor Emeritus of Pediatrics and Emergency Medicine at the University of Colorado School of Medicine, Chairman Emeritus, Micromedex, Inc., and Director Emeritus of the Rocky Mountain Poison Center of the Denver Department of Health & Hospitals, University of Colorado Health Sciences Center. His research interests include Acetaminophen Overdose and General Medical Toxicology. He has published over 250 peer-reviewed articles, authored or edited numerous books and book chapters. He is on the editorial board of a number of journals including Clinical Toxicology, Emergency Medicine, among others. He is a Fellow of the American Academy of Clinical Toxicology, American College of Medical Toxicology, and American Academy of Pediatrics and member of Society of Toxicology, American Association of Poison Control Centers, and American College of Emergency Medicine.

• Includes comprehensive coverage of the pharmacological mechanisms of toxicity
• Provides risk analysis regardless of patient presentation or timing of ingestion or amount with algorithmic support
• Covers how to determine level of toxicity and need for liver transplant with algorithmic support
• Outlines new therapeutic approaches