Angiogenesis, 2008
An Integrative Approach from Science to Medicine

History of Angiogenesis.- Angiogenesis and Vascular Remodeling: Biology and Architecture of the Vasculature.- Endothelial Cell Activation.- Pericytes, the Mural Cells of the Microvascular System.- Matrix Metalloproteinases and Their Endogenous Inhibitors.- Integrins in Angiogenesis.- Fibroblast Growth Factor-2.- Vascular Permeability Factor/Vascular Endothelial Growth Factor.- Platelet-derived Growth Factor.- Angiopoietins and Tie Receptors.- Basement Membrane-derived Inhibitors of Angiogenesis.- Endostatin and Angiostatin.- Thrombospondins.- Overview of Angiogenesis during Tumor Growth.- Hypoxic Regulation of Angiogenesis by HIF-1.- Regulation of Angiogenesis by von Hippel Lindau Protein and HIF2.- Nitric Oxide in Tumor Angiogenesis.- VEGF Signal Transduction in Angiogenesis.- Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis.- Immune Cells and Inflammatory Mediators as Regulators of Angiogenesis.- Contribution of Endothelial Progenitor Cells to the Angiogenic Process.- The Cancer Stem Cell Model.- Targeting the Tumor Microenvironment (Stroma).- Normalization of Tumor Vasculature and Microenvironment.- Targeted Drug Delivery to the Tumor Neovasculature.- Models for Angiogenesis.- Surrogates for Clinical Development.- Imaging of Angiogenesis.- Tumor Endothelial Markers.- Overview and Clinical Applications of VEGF-A.- Protein Tyrosine Kinase as Antiangiogenic Agents.- Therapeutic Strategies that Target the HIF System.- The Clinical Utility of Bevacizumab.- Development of Thalidomide and its IMiD Derivatives.- TNP-470: The Resurrection of One of the First Angiogenesis Inhibitors.- Clinical Development of VEGF Trap.- Recent Advances in Angiogenesis Drug Development.- Combination of Angiogenic Therapy with other Anticancer Therapies.- Immunotherapy of Angiogenesis with DNA Vaccines.- Challenges of Antiangiogenic Therapy of Tumors.- Pharmacogenetics of Antiangiogenic Therapy.- Angiogenesis in the Central Nervous System.-Lymphatic Vascular System and Lymphangiogenesis.- Ocular Neovascularization.- Angiogenesis and Pathology in the Oral Cavity.- Revascularization of Wound: The Oxygen-Hypoxia Paradox.- Journeys in Coronary Angiogenesis.- Perspectives on the Future of Angiogenesis Research.