Description
Revival: Biological Effects of Low Level Exposures to Chemical and Radiation (1992)
CRC Press Revivals Series
Coordinator: Calabrese Edward J.
Language: English
Subjects for Revival: Biological Effects of Low Level Exposures to...:
Keywords
Hormetic Dose Response; BIOCHEMICAL REACTION KINETICS; Alpha Crystallin; CARCINOGENESIS; Heat Shock; DOSE-RESPONSE RELATIONSHIPS; Irradiated Spleen Cells; RADIATION; Small Heat Shock Protein; TOXICITY; Hormetic Mechanisms; Harold Boxenbaum; Increased Liver Injury; Joan Smith-Sonneborn; Hormetic Response; Ronald Hart; Healthy Worker Effect; Ming Chou; Hepatocellular Regeneration; Ritchie Feuers; Ubiquitinconjugating Enzyme; Julian Leakey; Hormetic Effects; Peter Duffy; CR Result; Beverly Lyn-Cook; Gompertz Function; Jack Lipman; Tissue Repair Mechanisms; Kenji Nakamura; Heat Shock Response; Angelo Turturro; Hepatic Microsomal Cytochrome P-450; William Allaben; Irreversible Toxicity; Harihara M; Mehendale; Partial Hepatectomy; Robert E; Anderson; Age Specific Mortality; Emmanuel Farber; Hepatic ATP; Tom Downs; Liver Microsomal Cytochrome P-450; Hormetic Dose Response Model; Resistant Hepatocytes; DNA Repair
Publication date: 01-2019
· 15.6x23.4 cm · Paperback
Publication date: 08-2017
· 15.2x22.9 cm · Hardback
Description
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/li>Biography
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This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of biological adaptations. Hormesis is considered in a broad, conceptual manner, as well as at molecular and biochemical levels. Other topics covered include the effects of low levels of radiation on biological systems, how the liver adapts to genetic insults, biostatistical considerations when designing studies that address issues associated with biological responses to low doses of chemicals and radiation, and the issues that surround the interpretation of findings from such studies.
1.Hypotheses on Mammalian Aging, Toxicity, and Longevity Hormones 2. The Role of the ‘Stress Protein Response’ in Hormesis 3. DNA Repair 4. Biochemical Mechanisms of Biphasic Dose-Response Relationships 5. Effects of Low-Dose Radiation on the Immune Reponse 6. Cellular Adaption as an Important Response During Chemical Carcinogenesis 7. Bio statistical Approaches for Modelling U-shaped Dose-Response Curves and Study Design Considerations in Assessing the Biological Effects of Low Doses
Edward J. Calabrese is an American toxicologist and professor in the department of environmental health sciences at the University of Massachusetts Amherst. He is the editor-in-chief of the scientific journal Dose-Response.