Biomedical Applications of Magnetic Particles

Biomedical Applications of Magnetic Particles discusses fundamental magnetic nanoparticle physics and chemistry and explores important biomedical applications and future challenges.

The first section presents the fundamentals of the field by explaining the theory of magnetism, describing techniques to synthesize magnetic particles, detailing methods to characterize magnetic particles, and quantitatively describing the applied magnetic forces, torques, and the resultant particle motions. The second section describes the wide range of biomedical applications, including chemical sensors, cellular actuators, drug delivery, magnetic hyperthermia, magnetic resonance imaging contrast enhancement, and toxicity.

Additional key features include:

• Covers both introduction to physics and characterization of magnetic nanoparticles and the state of the art in biomedical applications
• Authoritative reference for scientists and engineers for all new or old to the field
• Describes how the size of magnetic nanoparticles affects their magnetic properties, colloidal properties, and biological properties.

Written by a team of internationally respected experts, this book provides an up-to-date authoritative reference for scientists and engineers.

Table of Contents

Foreword..........................................................................................................................................vii

Preface...............................................................................................................................................ix

Editor Bios........................................................................................................................................xi

List of Contributors ........................................................................................................................xiii

Chapter 1 Introduction to Biomedical Applications of Magnetic Nanoparticles.......................1

SECTION I Magnetic Particle Fundamentals

Chapter 2 A Conceptual Introduction to the Fundamentals of Magnetic Fields,

Magnetic Materials, and Magnetic Particles

for Biomedical Applications.......................................................................................7

Chapter 3 Magnetic Forces and Torques: Separation, Tweezing, and Materials

Assembly in Biology ................................................................................................33

Chapter 4 Colloidal Interactions of Magnetic Nanoparticles ...................................................59

Chapter 5 Magnetic Characterization: Instruments and Methods ............................................83

SECTION II Magnetic Particle Applications

Chapter 6 Synthesis and Functionalization of Magnetic Particles .........................................121

Chapter 7 Nanomagnetic Actuation: Controlling Cell Behavior with Magnetic

Nanoparticles...........................................................................................................159

Chapter 8 Magnetic Nanoparticles: Challenges and Opportunities in Drug Delivery ..........177

Chapter 9 Magnetic Particle Biosensors .................................................................................197

Chapter 10 Magnetic Contrast Imaging: Magnetic Nanoparticles as Probes in

Living Systems .......................................................................................................241

Chapter 11 Energy Dissipation by Magnetic Nanoparticles: Basic Principles

for Biomedical Applications ..................................................................................275

Chapter 12 Toxicology of Magnetic Nanoparticles .................................................................305

Index..............................................................................................................................................345

Jeffrey N. Anker is a Wallace R. Roy Distinguished Professor of Chemistry

and BioEngineering at Clemson University. He earned his BS degree in

applied physics at Yale University in 1998. He earned his doctorate at The

University of Michigan in 2005, working for Professor Raoul Kopelman

to develop magnetically modulated optical nanoprobes (MagMOONs) to

measure chemical concentrations and mechanical properties of solutions. For

this work, he was awarded a grand prize at the 2002 National Inventor’s

Hall of Fame Collegiate Inventor’s Competition. From 2005 to 2008,

Dr. Anker worked as an NIH National Science Research Award (NSRA)

postdoctoral research fellow at Northwestern University under the guidance of Professor

Richard Van Duyne. His postdoctoral research focused on developing real-time high-resolution

plasmonic nanosensors. He joined the Clemson Chemistry Department in August 2008. Current

research focuses on imaging and spectroscopy using magnetic, plasmonic, x-ray excited microand

nanosensors, implantable sensors, orthopedic devices, and medical imaging. Along with

Thompson Mefford, he founded the Frontiers in BioMagnetic Particles Meeting Series. Awards

include: NSF CAREER award (2013); Clemson Faculty Collaboration Award (2014); Clemson

University School of Health Research (CUSHR), and Greenville Health System Embedded

Faculty Fellow (2018); University Research, Scholarship, and Artistic Achievement Award

(USRAAA) (2018); and senior member of the National Academy of Inventors (2019).

O. Thompson Mefford is an Associate Professor in the Department of

Materials Science Engineering where he holds a David and Mary Ann Bishop

Dean’s Professorship, along with an additional appointment in the Department

of Bioengineering at Clemson University. He earned his BS degree

in Polymer and Textile Che