Description
Cancer and Noncoding RNAs
Translational Epigenetics Series
Coordinators: Chakrabarti Jayprokas, Mitra Sanga
Director of collection: Tollefsbol Trygve
Language: EnglishKeywords
Acetylation; Antisense RNA; Antitumor drug target; Bioinformatics; Biomarker; Body fluids; Cancer biomarker; Cancer hallmark; Cancer stem cell; Cancer; Carcinogenesis/tumorigenesis; ceRNA; Chromatin; circRNAs; Circular RNA; Circulating miRNA; Circulating noncoding RNAs; Codon; Competing endogenous RNA; Database; Development; Diagnosis; Diagnostic biomarker; DICER1 syndrome; Differentiation; DNA methylation; Epigenetic modifiers; Epigenetic regulation; Epigenetic; Epigenetics; Exosome; Extracellular vesicle; Extratranslational function; Focal amplification; Genetic alteration; Genetic mutation; Genetic variation; Genome instability; Genome-wide association studies; GWAS; Histone methylation; Histone modifications; HOTAIR; Imprinting; Leukemia; lncRNA; lncRNAs; Long noncoding RNA; Long noncoding RNAs; Lymphoma; Melanoma; Metastasis; Microarray; Microenvironment; Microprocessor complex; MicroRNA; MicroRNAs; Microvesicle; miRNA interference; miRNA; miRNAs; Myeloma; Natural antisense transcript; ncRNA; ncRNAs; Next-generation sequencing; Noncoding RNA; Noncoding RNAs; Oncogene and tumor suppressor; Oncogene; Pathway perturbation; Pathway; piRNA pathway; piRNAs; PIWI proteins; Piwi-interacting RNA; Prediction algorithm; Prognosis; Pseudogene; Quantitative real-time PCR; RISC; RNA modification; RNA sequencing; RNA-seq; Sarcoma; Self-renewal; Sensitivity; Signal transduction; Single cell RNA sequencing; Single-nucleotide polymorphism; siRNA; siRNAs; snoRNA; SNP; SNPs; Specificity; Stage; Stem cells; Stemness; Target; TERRA; Therapy; tiRNA; Tissue homeostasis; TNM; Transfer RNA modification; Translation; Transposable elements; tRFs; tRNA; tRNA-derived fragments; tRNAs; Tumor progression; Tumor suppressor; Tumorigenesis; Whole-genome sequencing; XIST
Support: Print on demand
Description
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Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches.
This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies.
1. Introduction
SECTION I: NON-CODING RNAs: FINE-TUNING CANCER 2. miRNA and Cancer: A Deadly Liaison? 3. Alteration of MicroRNA Biogenesis Pathways in Cancers 4. MicroRNAs In Exosomes in Cancer 5. Circulating miRNAs Incresaing the Risk of Cancer 6. Long Noncoding RNAs as Cancer Biomarkers 7. The Balancing Act: Understanding MicroRNA and Competing Endogenous RNA Regulation in Cancer 8. PIWI-Interacting RNAs (piRNAs) and Cancer 9. Transfer RNA in Cancer 10. Dynamic Regulation of tRNA Modifications in Cancer 11. Circular RNA: A Novel Noncoding RNA in Cancer 12. Antisense RNA and Cancer 13. Implication of Other Noncoding RNAs in Cancer
SECTION 2: GENETIC DYSREGULATION OF NON-CODING RNA IN CANCER 14. Noncoding RNA Alterations in Cancer Molecular Pathways 15. Genetic Alteration of MicroRNA Affecting Cancer Pathways 16. Genetic Variations of Long Noncoding RNAs in Cancer
SECTION 3: EPIGENETIC EFFECT ON CANCER THROUGH NON-CODING RNAs 17. Cross Talk Between Noncoding RNAs and DNA Methylation and Demethylation in Cancer 18. Noncoding RNAs Act as a Chromatin Scaffold of Histone Modification Complexes in Cancer 19. Heterochromatin Modulation and PcG Control of Gene Expression Medicated by Noncoding RNA in Cancer 20. Epigenetic Control of MicroRNA Expression and Cancer 21. Implications of Long Noncoding RNAs in Cancer Epigenetics
SECTION 4: THERAPEUTIC IMPLICATIONS OF NON-CODING RNA IN CANCER 22. Long Noncoding RNAs: Insight Into Their Roles in Normal and Cancer Stem Cells 23. Clinical Relevance, Prognostic Potential, and Therapeutic Strategies of Noncoding RNAs in Cancer 24. Noncoding RNAs: Novel Targets in Anticancer Drug Development
SECTION 5: BIOINFORMATICS' DETECTION OF NON-CODING RNA IN CANCER 25. Cancer Noncoding RNA Discovery Through High-Throughput Sequencing 26. Noncoding RNAs as a Cauce of Cancer: Evidence From Genome-Wide Association Studies and Reverse Genetics 27. A Comparative Evaluation of Emerging Databases and Tools for Cancer Noncoding RNAs 28. Future Directions and Challenges Involved in Cancer Noncoding RNomics
researchers, clinicians and graduate students in genomic medicine, epigenetics, and cancer research with an interest in developing RNA-based disease therapies
Since 2010 Sanga Mitra has served as a Senior Research Fellow at the Indian Association for the Cultivation of Science (IACS) in Kolkata, India, under the mentorship of her PhD advisor, Jayprokas Chakrabarti. Her research areas within the Computational Biology group at IACS include microarray and RNA-Sequencing data analysis, histone modifications, head and neck cancer, and tRNA gene annotation. She holds an M.S. in Bioinformatics and has recently submitted her PhD dissertation, “Computational Genomics and miRNomics of Cancer. Sanga
- Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics
- Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis
- Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies
- Features contributions by leading experts in the field
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