Controversies in Assisted Reproduction

Assisted Reproduction is a specialty undergoing rapid change as new technologies are introduced and new research challenges previous treatment options. This text examines a selection of controversial topics for both laboratory and clinical practice and tries to place them in perspective, so readers can understand how and why the current state of the question has come about and how future contributions to the debate should be measured. All physicians involved with the technologies concerned will learn from the expert contributions assembled here.

CONTENTS: The use of ovarian markers * Use of molecular markers of endometrial receptivity * Use of GnRHa for triggering final oocyte maturation during ovarian stimulation cycles * Use of time-lapse embryo imaging in assisted reproductive technology practice * Use of cryopreservation for all embryos * Preimplantation genetic screening * The use of single embryo transfer * Use of luteal phase support * Measuring safety and efficiency in in vitro fertilization * To flush follicles during egg collection or not * Use of blastocyst culture * Use of mitochondrial donation * Controversies in recurrent implantation failure: From theory to practice * Fibroids: To remove or not? * Limitations of endometrioma surgery in in vitro fertilization: Possibilities of early disease control

1.The Use of Ovarian Markers. 2.The Use of Molecular Markers of Endometrial Receptivity. 3. The Use of GnRHa for Triggering Final Oocyte Maturation during Ovarian Stimulation Cycles. 4. The Use of Time-Lapse Embryo Imaging in Assisted Reproductive Technology Practice. 5. Use of Cryopreservation for All Embryos. 6. Preimplantation Genetic Screening. 7. The Use of Single Embryo Transfer. 8. Use of Luteal Phase Support. 9. Measuring Safety and Efficiency in In Vitro Fertilization. 10. To Flush Follicles during Egg Collection or Not. 11. Use of Blastocyst Culture. 12. Use of Mitochondrial Donation. 13. Controversies in Recurrent Implantation Failure: From Theory to Practice. 14. Fibroids: To Remove or Not. 15. Limitations of Endometrioma Surgery in In Vitro Fertilization: Possibilities of Early Disease Control.

Botros Rizk, MD, MA, FRCOG, FRCS, HCLD, FACOG, FACS
Medical Director, California Elite Fertility, Pasadena, California, USA and Shanghai, China; President, Middle East Fertility Society; and formerly Professor and Head, Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, University of South Alabama, Mobile, Alabama, USA

Yakoub Khalaf, MB BCh, MSc, MD, FRCOG, MFFP
Professor of Reproductive Medicine and Surgery at Guy's and St Thomas' Hospital and King's College London, and Head of Fertility Service and Director of the Assisted Conception Unit and Centre for Pre-Implantation Genetic Diagnosis at Guy's and St Thomas’ Hospital, London, UK