Cyclin Dependent Kinase 5 (Cdk5), 2008

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

Will appeal to researchers from various fields of neuroscience research, in light of the extensive involvement of Cdk5 in neuronal development, plasticity and neurological disorders

Written by leaders in the field of Cdk5 research

Will encompass a variety of Cdk5 studies using different approaches to elucidate the functions and signaling mechanisms of Cdk5