Encyclopedia of Food Allergy

Encyclopedia of Food Allergy, organized in 10 sections, with ~200 chapters, and written by world-renowned clinician-scientist authors, is the most comprehensive resource for food allergy ever compiled. With online and physical presence, intuitive and easily accessible organization of information, the reader can quickly access overview and general topics as well as detailed information to inform solutions to clinical or research questions. Research topics provide the necessary background for the novice as well as the details required for those in the field. Clinical topics provide comprehensive and practical information, with generous use of tables, figures, and key points/clinical pearls, to inform clinical decision-making, and promote evidence-based management decisions. Food allergy may affect up to 10% of the population in developed countries and appears to be increasing in prevalence worldwide, with many food allergies proving life-long, severe and potentially fatal. The last decade has witnessed a sea change response to the impact of food allergy through basic science research on the immunology, food science research on the triggers, clinical approaches to daily management, treatment and prevention, and an increasing understanding of the psychosocial and societal implications and how to address them. With the expanding breadth and depth of the field, there is no existing comprehensive resource available for those professionals interested in learning about or contributing to food allergy research and clinical care. This is a complete resource covering broad and detailed aspects of food allergy and adverse food reactions for clinicians, researchers, regulators, food industry, students and other stakeholders who need and will benefit from a rich resource with in-depth and practical information.

Immunologic Sciences [15-20 chapters] -Mucosal immunity -Tolerance -Immunology of IgE mediated allergy -Immunology of non-IgE mediated allergy -B cell compartment -T cell compartment -Effector cells -Antigen presenting cells -Route of senstization -Mouse models -In vitro studies -Genetics of FA -Microbiome -Systems biology to understand food allergy Food sciences applicable to allergy (allergens, additives, toxins, measurement/detection)[30 chapters] -Molecular characteristics of food allergens -Nomenclature food allergens -Review of allergens Egg Milk Grains Soy and legumes Peanut Tree nuts Fish Shellfish Sesame and seeds Fruit allergy Vegetable allergy Cross reactivity Meat allergies (note alpha gal is covered under disease states) Allergy to protein additives/colors (carmine, pectin, gelatin, etc) -Genetic engineering -Thresholds -Labeling food allergens-studies -Labelling food allergens-laws -Allergen detection systems -Food additives and preservatives (multiple chapters with allergic implication -Sulfites -MSG -Tartrazine, azo/non-azo dyes, -Antioxidants, -Benzoates, parabens, -Colorings, flavorings, -Natural protein-based additives -Food toxins -Pharmacologic reactions to foods

Definitions, epidemiology, economics, quality of life, psychosocial impact [15-20 chapters] Food allergy definitions and overview (IgE, non-IgE, mixed] Food intolerance (break down types) Common food allergens and food groups/clinical implications and cross-reactivity Food allergy pediatric versus adult epidemiology Natural course of food allergy Tools for epidemiologic determination of food allergy Epidemiology of food allergy, prevalence Food allergy risk factors Economics Disparities Quality of life (QOL) QOL instruments Anxiety Bullying (not management)

Disease states of IgE mediated allergy [15-20 chapters] Atopic Dermatitis [diagnosis, management, role of food] Pollen-food related syndrome [overview, relationships, management] Urticaria/angioedema Respiratory tract Oral allergy syndrome/pollen-food allergy syndrome Food Induced Anaphylaxis Food associated exercise-induced anaphylaxis Alpha-gal allergy

Disease states of non-IgE mediated/mixed pathophysiology gastrointestinal allergy *each state likely needs sub-topics [15-20 chapters] Food protein induced enterocolitis syndrome [definitions, diagnosis, management, natural course] Food protein induced proctocolitis Eosinophilic esophagitis Eosinophilic gastritis Eosinophilic colitis Eosinophilic gastroenteritis Intolerance and other adverse reactions to foods [15-20 chapters] Overview Lactose intolerance Hereditary/metabolic disorders Alcohol dehydrogenase deficiency Celiac disease Role of food: colic, constipation Role of food: IBS, IBD Mast cell disorders and food allergy Autism/developmental disorders and foods Headaches and neurological issues and foods Rheumatologic diagnoses and foods Skin responses not related to atopic dermatitis or urticarial (FFE, physical urticarial) Primary immunodeficiency with implications for food allergy Asthma and food additives

Diagnostics [20-25 chapters] General approach (history, physical, prior probability assessment, test selection) Natural course related to diagnostics Skin tests Serum IgE with whole proteins Component tests Diagnostics with regard to cross-reactivity Epitope testing BAT MAT Elimination diets Oral food challenges (multiple) Incorporating history and testing Novel testing/monitoring Unproven methods Management [15-20 chapters] Nutrition topics (multiple and by ages), including daily management Occupational food allergy QOL/anxiety/bullying Age differences in management [infant/child/teen-young adult/adult] Restaurants School Anaphylaxis plans Label reading Home management Vaccine and medication allergies related to food allergies Lay organizations and general resources for food allergy Prevention [10-15 chapters] Overview of current recommendations (global) Role of maternal diet Role of breastfeeding Role of infant formula Early diet Microbiome/prebiotics/probiotics/synbiotics Skin barrier Diet diversity Nutrients, vitamin D Novel methods for primary and secondary prevention

Therapeutic approaches [15-20 chapters] Overview Oral immunotherapy [overview/approach/safety-efficacy others] Sublingual immunotherapy Immunotherapies with modified proteins or DNA vaccines Adjuvants Biologics-proteins Small molecule therapeutics Shared decision making for therapeutics Quality of life and therapeutics

• Presents in-depth, comprehensive coverage from an outstanding international author base of domain experts
• New researchers and clinicians will have a single resource that includes general topics to get them started
• Well-informed clinicians and researchers will have access to detailed information in their areas of work AND for many related topics that will help improve their research or clinical care
• A uniform chapter template will be used to ensure consistency throughout