Description
Epigenetics and Metabolomics
Translational Epigenetics Series
Coordinators: Agrawala Paban K., Rana Poonam
Director of collection: Tollefsbol Trygve
Language: EnglishKeywords
Aging; Analytical techniques; Atherosclerosis; Big data; Biochemical pathways; Burn; Cancer; Cardiovascular disease; Chemometrics; Chromatin; Clinical phenomics; Cytokines; Cytomegalovirus; Diet; DNA methylation; DNA methyltransferases; Double and triple burden; Dysbiosis; Embryonic development; Epialleles; Epigenetic; Epigenetic regulation; Epigenetic regulations; Epigenetics; Fibroblasts; Foam cells; Gastrointestine; GC; GC-MS; Gene expression; Genetic regulation; Gut microbiome; Hepatitis; Hepatocellular carcinoma (HCC); Histone acetylation; Histone deacetylases; Histone modification; Histone modifications; Host cell; Immune system; Inflammation; Inflammatory diseases; Ionizing radiation; LC-MS; LncRNA; Low-density lipoproteins; Macrophages; Malnutrition; Mass spectrometry; Metabolic mapping; Metabolism; Metabolites; Metabolomics; Methylomes; Microbiota; miRNA; MS; Mutations; Myc and epigenetics; NMR spectroscopy; Nonalcoholic fatty liver disease (NAFLD); Noncoding RNA; Nutrition in 1000days of life; Obesity; Oncogene gene; p53; Phenome; Plants; Plaque; Radiation; Ras; Rb; Stunting; Transcription; Traumatic brain injury; Vascular smooth muscle cells; Viral infection; Virus; Vitamins; Wound healing
476 p. · 19x23.4 cm · Paperback
Description
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Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare.
2. Integration of epigenomics and metabolomics: From biomarkers discovery to personalized medicine
3. Aging-associated changes in metabolic regulation of epigenetic modifications and gene expression
4. Epigenetic and metabolic changes in traumatic brain injury
5. Metabolic regulation in urological tumors: Interplay with epigenetics and epitranscriptomics
6. Multiomics approach for precision wellness
7. Oncogene: An epigenetic regulation
8. Epigenetic regulations in gastrointestine: Implications on sensitivity to ionizing radiation, inflammatory diseases, and cancer development
9. Epigenetics of epithelial to mesenchymal transition (EMT) in cancer
10. Nutrients seminal role in the development and epigenetic reprogramming during the first 1000 days of life
11. Epigenetic mechanisms of hepatocellular carcinoma progression: Potential therapeutic opportunities
12. Translational epigenetics in neurodegenerative diseases
13. Host-epigenetics-microbiota: A tripartite interaction in health and disease
14. Epigenetics in cardiovascular complications
15. Epigenetics and viral infectious diseases
16. Metabolic profiling leading to clinical phenomics: From bench to bedside
17. Epigenetic insights for wound healing mechanism
18. Role of metabolomics to investigate combined effect of radiation and burn
19. Advances and prospects of epigenetics in plants
Dr. Poonam Rana Phd is a Senior Scientist at the Institute of Nuclear Medicine & Allied Sciences, under Ministry of Defence, Delhi, India. She received her PhD at the CCS Haryana Agricultural University in Hisar, India. Her focus of research is applications of metabolomics and imaging in identification of biomarkers for traumatic brain injury and radiation exposure during combat emergencies. She has published widely in such peer reviewed journals as the Scientific Reports, Metabolomics, Journal of Neuroendocrinology, International Journal of Radiation Biology, Journal of Neuroscience Research, and Chemical Biological Interactions.
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He
- Offers a synthesized discussion of epigenetic regulation of metabolic activity and systems-based approaches to power new research
- Discusses epigenetic control of metabolic pathways and possible therapeutic targets for cancer, neurodegenerative, and neuroendocrine diseases, among others
- Provides guidance in epigenomics and metabolomic research methodology
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Epigenetics in Human Disease 170.55 €