Description
Fc Mediated Activity of Antibodies, 1st ed. 2019
Structural and Functional Diversity
Current Topics in Microbiology and Immunology Series, Vol. 423
Coordinators: Ravetch Jeffrey V., Nimmerjahn Falk
Language: EnglishSubjects for Fc Mediated Activity of Antibodies:
Publication date: 09-2020
Support: Print on demand
Publication date: 09-2019
Support: Print on demand
Description
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This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
IgG Fc receptors: evolutionary considerations.- Role of FcgRs in Antibody Based Cancer Therapy.- Anti-inflammatory Activity of IgG-Fc.- IgG Fc glycosylation in human immunity.- IgE Glycosylation in Health and Disease.- Immune Complex Vaccination.- Fc receptors in anti-microbial protection.
Jeffrey V. Ravetch
Theresa and Eugene M. Lang Professor
Department Leonard Wagner Laboratory of Molecular Genetics and Immunology
Rockefeller University
1230 York Avenue, Box 98
New York, NY 10021, USA
ravetch@mail.rockefeller.edu
Falk Nimmerjahn
Professor for Immunology and Genetics
Chairman of the Institute of Genetics
Head of the Department of Biology
Department of Biology
University of Erlangen-Nuernberg
Erwin-Rommelstr. 3
91058 Erlangen, Germanyfalk.nimmerjahn@fau.de
Examines the structural diversity of the Fc domain for IgG and IgE
Explores the role of Fc receptors in the context of infectious, autoimmune, and neoplastic disorders
Provides comprehensive information on Fc receptor pathways as an essential part of the immune response
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