Fungal Physiology and Immunopathogenesis , 1st ed. 2019
Current Topics in Microbiology and Immunology Series, Vol. 422

This volume offers an overview of the various aspects involved in the ability of fungi to damage host cells, and discusses cutting-edge approaches to the study of fungal pathogenesis. The first chapter illustrate the key roles of glycans and pigments, the most abundant surface components in fungal cells, in their interactions with host cells. The connections between cellular physiology and fungal pathogenesis are then discussed in the following chapters. Physiology-related processes affecting pathogenesis include fungal secretion, morphological transitions, and response to light.

In turn, the book illustrates mechanisms of damage to host cells using the Histoplasma capsulatum model of infection, and reviews the use of transcriptomic approaches to understand the mechanisms of interaction between fungal cells and host tissues. After a discussion of the immunological mechanisms underlying host susceptibility to fungal infections, the book?s closing contribution reviews the mechanisms of interaction between fungi and other microbes, and the impact of this association on fungal pathogenesis. Given its scope, the book will appeal to scientists in the fields of mycology, microbiology, infectious diseases, biology and medicine.

Candida morphology and pathogenesis.-  Fungal biofilms.- Immunoactive fungal vesicles.- Candida parapsilosis pathogenesis.- Fungal circadian clocks and pathogenesis.-  Cryptococcal pathogenesis.- Nucleic acid export in fungi.- Immunity to fungal infections.- Fungal systems biology.

Shares new insights into how fungal pathogens damage host cells

Covers key aspects of fungal pathogenesis and the mechanisms behind fungal virulence

Sheds new light on the high costs of, and elevated levels of toxicity in, antifungal therapy