Helicobacter pylori Infection, 1993
Pathophysiology, Epidemiology and Management

Now that Helicobacter pylori is generally accepted as a key aetiological agent in gastric cancer as well as the main agent in peptic ulcer, it can claim to be the most important new discovery in clinical gastroenterology of the last decade, and yet there is no up-to-date book available on the subject that is designed primarily for the clinical gastroenterologist. This book aims to fill that niche. It should also be of interest to the basic scientist, to those providing a clinical laboratory service (microbiologists and histopathologists), and to epidemiologists and others involved in clinical research.

1 Historical and microbiological perspectives.- Epidemiology.- 2 Geographical distribution and association with gastric cancer.- 3 Natural history and mode of transmission.- Pathophysiology.- 4 Pathogenesis of infections due to persistent bacteria at mucosal surfaces.- 5 Host responses.- Role in Peptic Ulcer Disease.- 6 Acid secretion.- 7 Mucosal defence.- 8 Overview.- Role in Gastric Cancer.- 9 The precancer—cancer sequence.- 10 Biochemical aspects.- Diagnosis.- 11 Histological diagnosis.- 12 Microbiological tests.- 13 Urea breath tests.- 14 Serology.- Treatment.- 15 Drug regimens.- 16 Vaccination: possibilities and probabilities.- Conclusion.- 17 Conceptual evolution from gastritis, to peptic ulcer and gastric cancer, to ‘cystitis of the stomach’ and, finally, to a smallpox equivalent.