Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders, 1st ed. 2019

This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders.

The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors? therapeutic efficacy against various neurological complications.

Chapter 1. Role of Epigenetics in neurological diseases.- Chapter 2. Epigenetic enzymes and the drawbacks of conventional therapeutic regimens.- Chapter 3. Distinct classes of HDACs.- Chapter 4. HDAC implications in neurological diseases.- Chapter 5. HDAC inhibitors and their structurally distinct groups.- Chapter 6. HDAC inhibitors as novel therapeutic option against therapeutically challenging neurological disorders.- Chapter 7. Current Challenges with HDAC inhibitor based therapeutic intervention against neurological maladies.- Chapter 8. Escalating need of isoform selective inhibitors for enhanced therapeutic efficacy.- Chapter 9. Combinatorial therapeutic regimens using HDAC inhibitors in conjunction with conventional therapeutic agents.- Chapter 10. Future directions of epigenetic research in tackling neurological complications.

Dr. Shabir Ahmad Ganai is currently working as Assistant Professor Cum Junior Scientist, Division of Basic Sciences and Humanities, Faculty of Agriculture, SKUAST-Kashmir, Wadura, Sopore, 193201, Jammu & Kashmir, India. He has done his masters in Biochemistry from Bangalore University (2005-2007) and earned his Ph.D. from elite SASTRA University (2009-2014). Later, he did his post-doctorate from National Brain Research Centre, Haryana, India. He has also served as research fellow in SKUAST-Kashmir. His research interests are focused on understanding the modulations of the nuclear geometry and post-translational modifications during treatment with structurally distinct HDAC inhibitors. He has been actively involved in designing the target-selective inhibitors against Class II HDACs using various bioinformatics tools.

This book is first of its kind that summarizes the role of the 18 isoforms of Histone deacetylase (HDAC) in different neurodegenerative disorders

It uniquely highlights the potential of various HDAC inhibitors as therapeutic agents against different neurological disorders

It provides an updated account of the various approaches to design the selective inhibitors as targets against Classical HDACs

It comprehensively enriches the understanding of the synergistic therapeutic approaches for mitigating the dose limited effects of HDAC inhibitors