Homocysteine Metabolism in Health and Disease, 1st ed. 2022

This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.

Prof. Govind Prasad Dubey is designated as a Lifelong Distinguished Professor at Department of Kriya Sharira; and has profound expertise in scientific validation of Indigenous System of Medicine. He also bears the responsibility of Study Director and Coordinator, DST Tribal Medicine Project, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh. Prof. Dubey has more than 50 years of teaching, research and administrative experience and has been felicitated with various posts of International and National significance. He is distinguished member of several scientific committee including, Indian delegation led by Prime minister of India to USA. Prof. Dubey has received several International and Nation Funds/Grants including; Department of AYUSH, Department of Science and Technology (DST), Department of Biotechnology (DBT), Indian Council of Medical Research (ICMR), New Delhi and other government body in collaboration with multinational companies including; Jinvator BioMed GmbH, Germany in different areas of Herbal/Ayurveda drug development. He has published more than 250 research articles, 05 books, and holds 24 patents of USA, European and Indian continent.

Prof (Mrs.) Krishna Misra is an Honorary Professor, Indian Institute of Information Technology, Prayagraj, U.P. She superannuated as a Professor of Chemistry at University of Allahabad, where she occupied the chair of head, Biochemistry department and was first coordinator of the Centre for Biotechnology. At present, she is fellow of The National Academy of Sciences, Allahabad and also worked as General Secretary. Besides, she is chief advisor, India Pesticides Ltd., Lucknow and had been member advisory board, Biotech Park, Lucknow. She was awarded NASI Platinum Jubilee senior scientist Fellowship. She is chairperson of STEM program of DST and Chemistry advisory board of UPCST. She had been expert in many selection committees including KGMU, SGPGIMS Luc