Textbook of Immunopsychiatry
An Introduction

The rapidly growing field of immunopsychiatry combines expertise and insights from immunology, psychiatry and neuroscience to understand the role of inflammation and other immune processes in causing and treating mental illness. This represents a major shift in mental health science, traditionally focused on psychological and neuronal mechanisms of depression, psychosis and dementia. This book provides the first comprehensive overview of recent, inter-disciplinary research linking disordered function of the immune system to the brain and mental illness. It offers a broad and deep perspective on the implications of immune system involvement in psychiatric disorders, including a balanced focus on basic science and clinical applications. Chapters cover the scientific evidence linking immune processes to major mental illnesses such as schizophrenia, depression, anxiety and dementia. An invaluable guide for graduate students, doctors in training, scientific researchers and others interested in the link between the immune system and mental health.

Preface; 1. Basic concepts in immunobiology Lorinda Turner and Neil Harrison; 2. From Psychoneuroimmunology to immunopsychiatry: an historical perspective Keith W. Kelley; 3. Stress, immune system and brain Julie-Myrtille Bourgognon, Alison McColl, Maria Suessmilch, Rajeev Krishnadas and Jonathan Cavanagh; 4. The role of prenatal and childhood infection and inflammation in schizophrenia Carly Apar, Fiona Conway, Genevieve Falabella and Alan S. Brown; 5. The role of autoimmune encephalitis in immunopsychiatry and lessons from neuropsychiatric systemic lupus erythematosus Esha Abrol and Mike Zandi; 6. Effectiveness of immunotherapies for psychotic disorders Rachel Upthegrove and Bill Deakin; 7. Inflammation, sickness behaviour and depression Golam Khandaker, Alessandro Colasanti and Neil Harrison; 8. Immunotherapies for depression Nils Kappelmann, Edward T. Bullmore, and Golam M. Khandaker; 9. The effect of systemic Inflammation on cognitive function and neurodegenerative disease Colm Cunningham and Donal Skelly; 10. Role of Inflammation in Lewy body dementia Ajenthan Surendranathan, and John T O'Brien; 11. The role of adaptive and innate immunity in alzheimer's disease Clive Holmes; 12. The immune system and anxiety disorders Vasiliki Michopoulos and Tanja Jovanovic; 13. Microbiome-gut-brain interactions in neurodevelopmental disorders: focus on autism and schizophrenia Kiran Sandhu, Eoin Sherwin, Ted Dinan and John Cryan; 14. Depression and the adaptive immune system Robert Dantzer; 15. Transdiagnostic features of the immune system in major depressive disorder, bipolar disorder and schizophrenia Célia Fourrier, Catherine Toben, and Bernhard T. Baune.

Golam Khandaker is Professor of Psychiatry and Head of Immunopsychiatry and Experimental Medicine Programme at the MRC Integrative Epidemiology Unit, University of Bristol, UK. He is a Wellcome Trust Fellow (University of Bristol and University of Cambridge), and Honorary Consultant Psychiatrist in the UK National Health Service.
Neil Harrison is Professor of Psychiatry and Clinical Director of Cardiff University Brain Research Imaging Centre (CUBRIC), UK.
Edward Bullmore is Professor of Psychiatry and Deputy Head of the School of Clinical Medicine at the University of Cambridge, and Director of R&D at Cambridgeshire & Peterborough NHS Foundation Trust.
Robert Dantzer is Professor in the Department of Symptom Research at The University of Texas MD Anderson Cancer Center in Houston, Texas.