Investigative Electrocardiography in Epidemiological Studies and Clinical Trials, 2007

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Language: English

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Investigative Electrocardiography in Epidemiological Studies and Clinical Trials
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289 p. · 17.8x25.4 cm · Paperback

Approximative price 158.24 €

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Investigative electrocardiography in epi demiological studies & clinical trials
Publication date:
289 p. · 17.8x25.4 cm · Hardback

This provides background information on procedures, epidemiological aspects, problem areas, mortality and morbidity risk. These topics are of particular interest for investigators in ECG research and clinical trials. This monograph is specialized beyond the scope of ordinary clinical textbooks of electrocardiography that have traditionally flooded the market. The authors have closely collaborated for over a quarter of a century in operating an academic ECG Center.

Investigative Electrocardiography in Epidemiological Studies and Clinical Trials.- Cardiac Excitation and Repolarization.- Electrocardiographic Lead Systems.- Normal and Arrhythmogenic Ionic Channel Mechanism.- Heart Rate and Heart Rate Variability.- Methodological Considerations in Heart Rate Variability Analysis.- Supraventricular Dysrhythmias.- Ectopic Ventricular Activity.- Record Length, Spontaneous Variability and Suppression of Ectopic Ventricular Complex Activity by Drugs.- Left Ventricular Hypertrophy.- Normal Standards for Cornell Voltage, Cornell Product and Sokolow-Lyon Voltage.- Prolonged Ventricular Excitation.- Old Myocardial Infarction.- Attributable Risk.- Primary Repolarization Abnormalities.- Procedures for Determination of the Spatial QRS/T Angle from Conventional ECG Measurements.- QT Prolongation and QT Dispersion — a Critical Evaluation.- Normal ECG Standards for Adults by Gender, Age, and Ethnicity.- ECG Intervals: Tables.- ECG Wave Amplitudes*: Tables.- ECG Vector Components and Spatial Magnitudes at Normalized Time Scale: Tables.- ECG Amplitudes at 10ms Intervals: Tables.- Repolarization Waveform Vectors: Tables.

The authors have closely collaborated for over a quarter of a Century in operating an academic ECG Center that has been in charge of ECG analysis of all major national health surveys conducted by the US National Center for Health Statistics, a series of large cardiovascular observational studies and clinical trials conducted by the US National Heart, Lung, and Blood Institute and several large clinical trials sponsored by pharmaceutical industry.

Comprehensive, penetrating, critical analysis of problems in such areas as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction, epidemiological consideration of relative risks associated with ECG abnormalities

Includes supplementary material: sn.pub/extras