JAK-STAT Signaling in Diseases

JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis.

Features:

• Details activation and microRNA-mediated regulation of JAK-STAT pathway
• Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe
• Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway.

An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.

Preface. Editor. List of Contributors. Regulation of Cytokine Signaling by the JAK-STAT Pathway.The Structure-Function Bonhomie of JAK-STAT Molecules. MicroRNA-Mediated Regulation of JAK-STAT Signaling in Non-Cancerous Human Diseases. JAK-STAT Signaling in Asthma and Allergic Airway Inflammation. Role of JAK-STAT Signaling in Atopic Dermatitis. JAK-STAT Signaling Pathway and Gliosis in Neuroinflammatory Diseases. JAK-STAT Signaling in Cardiovascular Disease. Diabetes and Obesity: Abnormal JAK-STAT Signaling. JAK-STAT Signaling in Liver Fibrosis. Renal Disorders: Involvement of Jak-STAT Pathway. JAK-STAT Signaling in Hematologic Malignancies. Aberrant JAK-STAT Signaling in Hematopoietic Malignancies. Immunodeficiency: Consequences of Mutations in JAK-STAT Signaling. Targeting JAK-STAT Pathway for Various Inflammatory Diseases and Viral Infections. Index.

Ritobrata Goswami, PhD is presently working as an Assistant Professor in the School of Bioscience, IIT Kharagpur since 2016. Prior to his present affiliation, Dr Goswami was associated with the Division of Biological and Life Sciences, Ahmedabad University (2014-16). He received his bachelor (2005) and masters degree (2007) in Biotechnology from West Bengal University of Technology and Birla Institute of Technology & Science, Pilani; respectively. Dr Goswami obtained his PhD at Indiana University, Indianpolis, USA (2012) followed by post-doctoral training at the Icahn School of Medicine at Mount Sinai, New York, USA (2012-14). He is a life member of the Indian Immunology Society. Dr Goswami has extramural projects funded by the Government of India. Dr Goswami’s research interests include the role of nutrients and hormones in the development and function of T helper cells to regulate inflammatory disorders. He is keen on identifying a regulating network of transcription factors involved in autoimmune and inflammatory disorders so that better therapeutics can be developed.