Description
Management of Soft Tissue Sarcoma (2nd Ed., Softcover reprint of the original 2nd ed. 2016)
Authors: Brennan Murray F., Antonescu Cristina R., Alektiar Kaled M., Maki Robert G.
Language: EnglishSubject for Management of Soft Tissue Sarcoma:
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Add to cart the print on demand of Brennan Murray F., Antonescu Cristina R., Alektiar Kaled M., Maki Robert G.Publication date: 12-2016
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Add to cart the print on demand of Brennan Murray F., Antonescu Cristina R., Alektiar Kaled M., Maki Robert G.Publication date: 04-2018
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/li>Biography
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Management of Soft Tissue Sarcoma
Table of Contents
Preface
Part I Introduction
1. General Description
· Introduction· Incidence and Prevalence
· Predisposing and Genetic Factors
· References
2. Natural History – Importance of Size, Site, Histopathology
· Natural History
· Influence of Site
· Staging
· Staging of Retroperitoneal Visceral Sarcoma
· Prognostic Factors for Extremity and Superficial Soft Tissue Sarcoma
· Disease-Specific Survival
· Prognostic Factors for Survival Following Local Recurrence of Extremity Sarcoma
· Prognostic Factors: Nomograms· References
3. General Statement as to Efficacy Surgery / Chemotherapy / Radiation Therapy
· Extent of primary surgery
· Surgical Treatment of Local Recurrence
· Diagnostic Imaging
· Surgery for Metastatic Disease
o Pulmonary Metastasis
o Surgery and the Management of Sarcoma Liver Metastasis
· Radiation Therapy
o Adjuvant Radiation Therapy
o Dose of Radiation Therapy
o Adjuvant Brachytherapy
o Radiation Therapy in the Presence of Positive Microscopic Marginso Definitive Radiation Therapy
o Radiation to Patients with Neurovascular Involvement
o Wound Complications of Radiation Therapyo Adjuvant and Neoadjuvant Chemotherapy for Soft Tissue Sarcomas
o Sarcomas More Common in Adults
o Larger Randomized Studies
o Selected Meta-analyses of Randomized Trials of Adjuvant Chemotherapy
o Adjuvant Therapy for GIST
o Sarcomas More Common in Pediatric Setting
o Brief comments regarding chemotherapy for metastatic soft tissue sarcoma
o Newer Systemic Agents
· Special Techniques for Primary & Locally Recurrent Disease
o Intra-arterial Chemotherapy
o Limb Perfusion and Hyperthermia
o Immunotherapy for Sarcomas
<· References
Part II Management by Histopathology
4. Gastrointestinal stromal tumor
· Imaging
· Familial GIST
· Natural History
· Diagnosis / Molecular Pathology
· Treatment
o Adjuvant Imatinib for Primary GIST
o Neoadjuvant Therapy for Primary Disease not amenable to Surgery<
o Treatment of Recurrence
o Imatinib: The First Small Molecule Oral Kinase Inhibitor for Metastatic GIST Failing Imatinib & Sunitinib
o Systemic Targeted Therapy for Metastatic GIST
o Dose Intensity over Timeo Imatinib Pharmacokinetics
· Second-Line Sunitinib for Imatinib-Resistant Metastatic GIST
o Other Tyrosine Kinase Inhibitors for Metastatic GIST
o Failing Imatinib and Sunitinib
o GRID Trial
· Newer Agents for GIST
· References
5. Liposarcoma
· Imaging
· Diagnosis
· Treatment
· Radiation Therapy for Liposarcoma
· Systemic Therapy: General Considerations· Adjuvant Therapy
· Treatment of Metastatic Disease
· Outcome· Outcome Following Metastasis
· References
6. Leiomyosarcoma
· Imaging
· Diagnosis, Molecular Pathology
· Primary Treatment
· Radiation Therapy
· Systemic Therapy
o Adjuvant Chemotherapy for Leiomyosarcoma
· Outcomes after Primary Therapy
· Patterns of Recurrence
· Treatment of Recurrence
· Metastatic Disease
· References
7. Undifferentiated Pleomorphic Sarcoma (UPS) (Malignant Fibrous Histiocytoma: MFH) Myxofibrosarcoma
· Imaging
· Diagnosis, Molecular Pathology
· Natural History
· Treatment
· Radiation Therapy
· Metastatic Disease
· Adjuvant Chemotherapy· Outcome
· References
8. Synovial Sarcoma
· Imaging
· Diagnosis, Molecular Pathology
· Treatment
· Radiation Therapy
· Chemotherapy
· Treatment of Recurrence
o Local Recurrence
o Systemic Treatment
· Outcome
· References
9. Malignant Peripheral Nerve Sheath Tumor (MPNST) / Triton Tumor
· Presentation
· Imaging
· Diagnosis, Pathology
· Neurofibromatosis Type 1 and Outcome
· Treatment
· Radiation Therapy
· Chemotherapy for MPNST
· Outcome· References
10. Desmoid Tumor / Deep-Seated Fibromatosis (Desmoid-Type Fibromatosis)
· Clinical Presentation
· Imaging
· Diagnosis, Molecular Pathology
· Natural History· Treatment
· Treatment of Recurrence
<· Systemic Therapy
· Treatment by Observation
· Radiation Therapy
· Patterns of Failure
· Outcome
· References
11. Solitary Fibrous Tumor / Hemangiopericytoma
· Doege-Potter Syndrome
· Primary Therapy
· Systemic Therapy for Metastatic Disease
· Outcome
· References
12. Fibrosarcoma and its Variants
· Outcome
· Dermatofibrosarcoma Protuberans
· Outcome
· Low-Grade Fibromyxoid Sarcoma (of Evans Tumor)
· Outcome
· Sclerosing Epithelioid Fibrosarcoma
· Inflammatory Myofibroblastic Tumor· Infantile Fibrosarcoma
· Myxoinflammatory Fibroblastic Sarcoma / Inflammatory Myxohyaline Tumor of Distal Extremities
· Adult-Type Fibrosarcoma· References
13. Vascular Sarcomas
· Epithelioid Hemangioendothelioma· Angiosarcoma / Lymphangiosarcoma
· Outcome
· Kaposi Sarcoma· References
14. Epithelioid Sarcoma
· Outcome
· References
15. Sarcomas More Common in Children
- Ewing Sarcoma Family of Tumors (EFT)
- Demographics
- Primary Therapy
- Adjuvant Chemotherapy
- High-Dose Systemic Therapy for Metastatic Disease
- Standard Cytotoxic Chemotherapy After Disease Relapse
- Investigational Approaches
- Ewing Sarcoma-Like Tumors
- Rhabdomyosarcoma
- Demographics
- Molecular Biology
- Risk Stratification
- Staging
- Imaging Primary Therapy
- Chemotherapy for Metastatic Disease
- Embryonal Sarcoma
- References
- Soft Tissue Sarcomas More Commonly Observed in Pediatric Patients
16. Radiation-Induced Sarcoma
· References
17. Alveolar Soft Part Sarcoma
· Imaging
· Diagnosis, Molecular Pathology
· Primary Treatment
· Treatment of Metastatic Disease
· Outcome
· References
18. Clear Cell Sarcoma / Melanoma of Soft Parts
· Imaging
· Diagnosis, Molecular Pathology
· Treatment
· Outcome
· 19. Desmoplastic Small Round Cell Tumor · Imaging · Diagnosis · Treatment · Outcome · References 20. Extraskeletal Myxoid Chondrosarcoma · Imaging · Diagnosis
· Outcome
· Mesenchymal Chondrosarcoma
· References
21. Other Uterine Sarcomas
· Low Grade Endometrial Stromal Sarcoma
o Diagnosis
o Treatment
o Outcome
· High Grade Endometrial Stromal Sarcoma
o Outcome· Undifferentiated Uterine Sarcoma (UUS)
· Uterine Carcinosarcomas and Other Malignant Mixed Müllerian Tumors
· PEComaso Outcome
· References
22. Extraskeletal Osteogenic Sarcoma
· Imaging
· Diagnosis
· Treatment
· Outcome
· References
23. Sustentacular Tumors of Lymph Tissue
· Follicular Dendritic Cell Tumor (Dendritic Reticulum Cell Tumor [FDCT]) and Interdigitating Reticulum Cell Tumor (IDRCT)
· True Histiocytic Sarcoma
· Langerhans Cell Tumors
· Outcome
· References
24. Uncommon / Unique Sites
· Heart and Great Vessels
· Primary Sarcomas of the Breast
o Phylloides Tumor
o Diagnosiso Outcome
· Head and Neck
o Treatment
· Primary Sarcomas of the Mediastinum
· Liver
· Part III Benign and Less Aggressive Lesions 25. Mostly Benign / Rarely Metastasizing · Ossifying Fibromyxoid Tumor · Perivascular Epithelial Cell Tumor (PEComa) & Related Entities, Lymphangioleiomyomatosis, Angiomyolipoma, and Sugar Cell Tumor · Therapy · Giant Cell Tumor of Tendon Sheath / Pigmented Villonodular Synovitis · Myoepithelioma of Soft Tissue · Glomus tumor <· References 26. Benign Tumors · Lipoma
· Lipoblastoma / Lipoblastomatosis
· Angiolipoma
· Angiomyolipoma
· Angiomyelolipoma
· Hibernoma
· Elastofibroma
· Granular Cell Tumor
· Hemangioma
· Leiomyoma
· Schwannoma
· Neurofibroma
· Myxoma
· Angiomyxoma
· Angiofibroma
· References
27. Reactive Lesions
· Myositis Ossificans· Nodular Fasciitis
· Sarcoma Masquerade
· References
Suggested Keywords
Index
Written by world renowned experts
Includes up-to-date data since last edition and an expanded chapter on radiation therapy
Only book where specific recommendations on chemotherapy as a function of specific subtypes are discussed
Covers surgical treatment, chemotherapy, radiation therapy, and novel pharmacotherapy
Gives a practical, up-to-date approach to all the different subtypes of adult soft tissue sarcoma
Includes supplementary material: sn.pub/extras
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