Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases , 1st ed. 2018

This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors. In addition, this book provides a comprehensive overview about the abnormalities of P2Y/TGR5 receptors and their contribution in the development and progression of pathological conditions. It also covers the currently available natural, chemical and pharmacological agents targeting these two receptor families and their therapeutic implications in P2Y and TGR5 associated disorders. This book is a valuable source for beginners and researchers to follow the rapidly progressing field of these two GPCR subfamily members.

Module 1_Overview of G-Protein coupled receptor.- Chapter 1. General Introduction.- Chapter 2. General Classification.- Chapter 3. Role of GPCR receptors - In development and Physiology.- Chapter 4. Metabotropic Receptors - Sub family and Distribution.- Module 2_TGR5 receptor.- Chapter 5. Introduction.- Chapter 6. Plasma Membrane receptors [TGR5].- Chapter 7. Nuclear Membrane receptors [FXR].- Chapter 8. Gene expression and signaling pathways of TGR5 receptors.- Chapter 9. Physiological and pathological role of TGR5 receptors.- Chapter 10. Summary.- Module 3_P2Y receptor.- Chapter 11. Introduction.- Chapter 12. P2Y receptor expression and Regulation.- Chapter 13. Signaling Pathways of P2Y receptors.- Chapter 14. Physiological Role of P2Y.- Chapter 15. P2Y in pathophysiology (Renal, Lungs, Cardiovascular system, Brain, etc).- Chapter 16. Summary.- Module 4_Therapeutically Targeting TGR5 & P2Y receptors.- Chapter 17. Introduction.- Chapter 18. Agonist and Antagonists of TGR5 & P2Y receptors.- Chapter 19. Pharmacological agents targeting TGR5 and its clinical benefits.- Chapter 20. Pharmacological Agents Targeting P2Y receptors and its clinical benefits.- Chapter 21. Conclusive Summary and Future Perspectives. 

Dr. Senthilkumar Rajagopal, is an Assistant professor at Rayalaseema University, Kurnool, AP, India and obtained his Ph.D. in Biochemistry from Annamalai University, INDIA.  He did his post-doctoral research in Anesthesiology in University of Virginia, Virginia, followed by Department of Cancer Immunology & AIDS, Dana Farber Cancer Institute, Harvard University, MA, USA and, Department of Physiology and Biophysics, Virginia Commonwealth University, Virginia, USA.  He is a recipient of Rameshwardasji Birla Smarak Kosh Endowment award from Mumbai Medical Trust, Mumbai, INDIA and Ramalingaswami Re-entry Fellowship from Department of Biotechnology, Ministry of Science and Technology, Government of India.  He has more than 10 years of research experience in various fields such as Alcoholic hepatotoxicity, voltage gated calcium channels, and protein kinase C phosphorylation, ADAM family, Smooth muscle physiology, G-protein coupled receptor signaling pathways, Neurotransmitters transporters to central nervous system. 

He has published nearly 48 research articles in various peer-reviewed international journals, 18 book chapters, and presented a research articles in number of conferences, proceedings and attended various workshops/seminars.  He is on the editorial/reviewer board in many peer-reviewed international journals such as Frontiers in Cellular Neuroscience, American Journal of Biochemistry and Molecular Biology, Neuroscience, etc.  He is member of various prestigious scientific associations like Indian Society for Atherosclerosis Research (ISAR), The International Science Congress Association (ISCA), Society of Biological Chemistry (SBC), Society for Free Radical Research India (SFRR), The Indian Society of Cell Biology (ISCB) and member of American Association of Pharmaceutical Scientists (AAPS) and Science Advisory Board (SAB). 

Dr. Murugavel Ponnusamy is presently working as Postdoctoral Research

This book provides up-to-date information on Bile acid regulatory functions and disorders

It uniquely covers diversity of metabotropic receptors signaling and applications of nanoparticles

It integrates physiology, biochemistry and pharmacological aspects of GPCR signaling

It includes easily understandable illustrations on GPCR mediated signaling in pharmacological disorders