Metal Toxicology Handbook

Heavy metals and metalloids, singly or in combination, induce toxic manifestations either through acute or chronic pathology. In particular, long-term chronic exposure to diverse heavy metals and metalloids to humans and animals can lead to numerous physical, muscular, neurological, nephrological, and diverse degenerative diseases and dysfunctions, including multiple sclerosis, muscular dystrophy, Parkinson?s and Alzheimer?s diseases, cardiovascular disorders, and several others.

Recognized heavy metals such as lead, mercury, arsenic, cadmium, thallium, and hexavalent chromium are known for enormous toxicity. The immediate vital signs of acute heavy metal exposure include nausea, vomiting, diarrhea, and acute abdominal pain. Mercury has been identified as the most toxic heavy metal, and mercury poisoning is known as acrodynia or pink disease. Similarly, lead, another toxic heavy metal, was at one time an integral part of painting.

Metal Toxicology Handbook further explains and discusses the varying attributes of metals, discussing toxicity, safety, and proper human utilization of metals. Beginning with a broad overview of metals, metalloids, redox biology, and neurodegeneration and going further into the roles, benefits, and toxicity of metals with each section, the text contains 28 chapters from eminent researchers and scientists in their respective fields and is a must-have for anyone researching the potential toxicity in metals.

Key Features

• Discusses the pathology of metal toxicity
• Highlights the benefits of metals
• Explains the mechanism and salient features of restoring metabolic homeostasis
• Highlights dose-dependent beneficial and adverse effects of vanadium safety and toxicity

The initial introductory section provides a broad overview of metals, metalloids, redox biology, and neurodegeneration. The second section discusses the pathology of metal toxicity in two chapters, while the third section highlights the mechanism and salient features of restoring metabolic homeostasis in two chapters. The fourth section demonstrates the aspect of radionuclides toxicity. In a change of pace, the fifth section discusses the benefits of metals in four chapters. The sixth section, titled "Toxic Manifestations by Diverse Heavy Metals and Metalloids," provides fourteen chapters that discuss the toxicological mechanism and manifestation of individual metals.

The editors have crafted a commentary titled "A Treatise on Metal Toxicity" and summarized a vivid scenario of metal toxicity and its consequences.

Part I: Introduction: Metals, Metalloids, Redox Biology, and Neurodegeneration 1. Role of Metals and Metalloids in Redox Biology 2. Role of Metals in Neurodegeneration Part II: Pathology of Metal Toxicity 3. Pathological Manifestations and Mechanisms of Metal Toxicity 4. An Overview of Heavy Metal Research in Traditional Chinese Medicine Part III: Mechanisms of Restoring Metabolic Homeostasis 5. Development and Utilization of a Novel Prodosomed-Electrolyte and Phytochemical Formulation Technology to Restore Metabolic Homeostasis 6. Gut Microbiome and Heavy Metals Part IV: Radionuclides Toxicity 7. A Review on Radionuclide Toxicity Part V: Benefits of Metals 8. Contribution of Bioavailable Silicon in Human Health 9. Benefits of Trivalent Chromium in Human Nutrition? 10. Trivalent Chromium: A Vital Insulin Sensitizer 11. Differential Impact of Organic Vanadium Compounds on Human Health: Deficiency States, Toxic Effects, and Potential Therapeutic Use 12. Vanadium—Speciation Chemistry Can Be Important When Assessing Health Effects on Living Systems Part VI: Toxic Manifestations by Diverse Heavy Metals and Metalloids 13. Clinical Toxicology of Copper: Source, Toxidrome, Mechanism of Toxicity and Management 14. Cadmium Exposure and Toxicity 15. Cobalt Toxicity and Human Health 16. Cobalt Toxicity 17. Iron-Siderophore and Tumorigenesis: Molecular Insight and Therapeutic Targets 18. Clinical Toxicology of Iron: Source, Toxidrome, Mechanism of Toxicity, and Management 19. Vanadium Toxicity Revisited: Striking the Right Balance between Potential New Generation Therapeutics and Adverse Side Effects 20. The Ubiquitous Lead—Biological Effects, Toxicity, and Management 21. Lead Toxicity: An Overview of Its Pathophysiology and Intervention Strategies 22. Arsenic Toxicity: Source, Mechanism, Global Health Complication, and Possible Way to Defeat 23. Clinical Toxicology of Mercury: Source, Toxidrome, Mechanism of Toxicity, and Management 24. An Overview of Tungsten Toxicity 25. Boron Toxicity: An Insight on Its Influence on Wheat Growth 26. Diversity of Mechanisms for Boron Toxicity in Mammals 27. Lithium: Is It Good or Bad for Plant Growth? 28. An Overview of Nickel Toxicity in Plants Commentary: A Treatise on Metal Toxicology