Molecular Determinants of Radiation Response, 2011
Current Cancer Research Series

Coordinators: DeWeese Theodore L., Laiho Marikki

Language: English
Cover of the book Molecular Determinants of Radiation Response

Subjects for Molecular Determinants of Radiation Response

Approximative price 158.24 €

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Molecular Determinants of Radiation Response
276 p. · 15.5x23.5 cm · Paperback

Approximative price 158.24 €

Subject to availability at the publisher.

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Molecular determinants of radiation response
276 p. · 15.5x23.5 cm · Hardback
Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

Molecular Basis of the DNA Damage Responses.- ATM signaling and DNA Damage.- H2AX in DNA Damage Response.- Dynamic Imaging of DNA Damage Foci.- DNA Damage Signaling Downstream of ATM.- Checkpoint Control and Radiation.- Chromatin Responses to DNA Damage.-DNA Damage Response and Senescence.- C. elegans and DNA Damage.- Modulation of Radiation Responses – Opportunities for Therapeutic Exploitation.- The Stem Cell and Radiation.- Role of the Cell Membrane in Signaling Radiation Injury.- Hypoxia and Modulation of Cellular Radiation Response.- Role of PARP and PARP Inhibition in Cellular Response to Radiation.- Anti-angiogenic Therapies and Radiation Responses.- Gene Therapy and Radiation.- Radiation-mediated Molecular Targeting.- EGFR Signaling and Radiation.- Heat and Heat Shock Proteins Modulation of Radiation Response.- Radiation-induced Immune Modulation.

Includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins Presents comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury A timely and relevant text for basic and translational researchers Includes supplementary material: sn.pub/extras