Nitric Oxide (Donor/Induced) in Chemosensitization
Cancer Sensitizing Agents for Chemotherapy Series

Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance.

This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy.

1. Nitric Oxide Mediated Chemosensitization: Gene Therapy Versus Exogenous Introduction of NO Donors2. Nitric Oxide Donors Sensitize Resistant Cancer Cells to Apoptosis Induced by Chemotherapy: Molecular Mechanisms of Sensitization3. RRx-001 Reset: Chemoresensitization Via NO-Mediated M1 Macrophage Repolarization4. Nitric Oxide and Nitric Oxide-Donors in Pre-Clinical Studies of Breast and Prostate Cancer5. Evaluation of the Impact of Nitric Oxide on Resistance to Platinum-Based Chemotherapeutics6. Nitric oxide and platinum derivatives-based regimens for cancer treatment: from preclinical studies to clinical trials7. NO-H₂S Releasing Chimeras as a Multifaceted Approach to Cancer Therapy8. Nitric Oxide-based Anticancer Therapeutics: The New Technologies of The Nanoparticles9. Nitric Oxide in Rectal Cancer: from Mice to Patients10. Chemoprotective and Chemosensitizing Effects of Nitric oxide and Other Biologically Active Gases in Breast Cancer Chemotherapy: Potential Implications11. Role of Nitric Oxide in Cancer Stem Cell Regulation and Metastasis 12. Nitric Oxide Interacting with Glutathione Transferases 13. Application of MRI to Study the Role of Nitric Oxide in Cancer Therapy14. S-Nitrosothiol Metabolism In Cancer And Therapeutic Implications

cancer researchers; oncologists; pharmacists; graduate students on cancer studies

Dr Bonavida has vast expertise and various reported publications in the field of tumor cell sensitization to chemotherapy (a total of greater than 500 publications) and in particular the novel role of Nitric Oxide (NO) donors in chemo-sensitization and reversal of drug resistance. In addition, he was the first scientist to co-organize an international meeting on the topic (First International Workshop on NO and Cancer, 2005).

• Brings updated information as reviewed by experts in the field
• Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients
• Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations