Pharmacology and Therapeutics of Airway Disease (2^nd Ed.)

Emphasizing state-of-the-art pharmacological and therapeutic approaches in controlling pathophysiological processes in the airways, Pharmacology and Therapeutics of Airway Disease reviews normal and abnormal physiological, biochemical and molecular aspects of the respiratory tract.Covering the basic mechanisms of inflammatory cell activation and pathophysiology in disease, therapeutic ways of controlling inflammation, reversing or preventing airflow obstruction, and symptomatic treatments of advanced disease.

Written as a concise clinical reference guide covering the current and future airway disease treatments, this text encompasses:

pathophysiology of respiratory tract diseases

the methods of measuring airway and clinical responses

the concepts upon which many treatments are used in COPD and asthma conditions

the way in which these treatments work, and how new treatments can be discovered and tested in various patient groups

state-of-the-art pharmacological and therapeutic approaches in controlling pathophysiological processes in the airways

normal and abnormal physiological, biochemical and molecular aspects of the respiratory tract

basic mechanisms of inflammatory cell activation and pathophysiology in disease

therapeutic ways of controlling inflammation

ways of reversing or preventing airflow obstruction, and symptomatic treatments of advanced disease

Preface/Introduction. Part 1: Principles and practice. Principles of pharmacology and therapeutics. Clinical trials in airways disease. Assessment of responses of the airways to therapeutic agents. Pharmacogenetics and pharmacogenomics of airways disease. Delivery of drugs to the airways and lungs. Part 2: Drugs in respiratory diseases. Corticosteroids in airways disease. Bronchodilator therapy in airways disease. Anti-mediator therapy. Cytokines and anti-cytokines. Anti-allergic approaches in airways disease. New anti-inflammatory approaches to therapy of airways disease. Part 3: Therapeutics and treatment approaches. Airway wall remodelling as a concept for airways disease therapeutics. Exacerbations of airways disease. Pharmacology and therapeutics of COPD. Pharmacology and therapeutics of asthma. Pharmacology and therapeutics of cough.