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Pharmacology of the Skin Routledge Revivals Series

Langue : Anglais

Coordonnateur : Mukhtar Hasan

Directeur de Collection : Hollinger Mannfred A.

Couverture de l’ouvrage Pharmacology of the Skin
First published in 1992, this book presents a balanced, state-of-the-art summary of pharmacology as it relates to the skin. Topics discussed include structure of the skin and its barrier function; model systems for research in skin pharmacology; the drug metabolizing capability of the skin, skin pharmacology in health and disease; the role of oxidants and antioxidants in the skin; immunopharmacology of the skin; signal transduction, protein kinase C and the role of the eicosanoid receptors in skin; and cutaneous chemical- and photo-carcinogenesis. Pharmacology of the Skin provides essential information for investigators working in cutaneous biology, investigative and clinical dermatologists, pharmacologists, pharmacists, biochemists, and workers in the pharmaceutical industry engaged in drug development.

Part I: Skin and Its Barrier Function. 1. The Structure and Function of Skin. 2. Percutaneous Absorption. 3. Role of Lipids in Barrier Function of the Skin. Part II: Skin Model System. 4. Skin Xenografts and their Utility in Pharmacologic Research. 5. Transdermal Drug Delivery Systems. Part III: Drug Metabolism in Skin. 6. Cutaneous Metabolism of Xenobiotics and Steroid Hormones. 7. Cutaneous Glutathione S-Transferases. 8. Cutaneous Glutathione S-Transferases. 9. Cutaneous Cytochrome P-450. Part IV: Skin Pharmacology in Health and Disease. 10. Drug-Induced Skin Disorders. 11. Retinoid Pharmacology and Skin. 12. Vitamin D₃: Synthesis and Biologic Functions in Skin. 13. Pharmacology of the Aging Skin. 14. Pharmacology of Psoralen Photochemotherapy. Part V: Oxidants and Antioxidants in Skin. 15. Sunscreens: Principles of Photoreception. 16. Antioxidants in the Skin. 17. Role of Reactive Oxygen Species in Skin. Part VI: Immunopharmacology of the Skin. 18. Pharmacology of Cytokines in the Skin. 19. Therapeutical Aspects of ICAM-1 Regulation in the Skin. Part VII: Signal Transduction and Eicosanoid Receptor in Skin. 20. Epidermal Eicosanoid Receptors. 21. Significance of Inositol Phospholipid Metabolism/Signal Transduction in the Skin. 22. Biochemical Pharmacology of Protein Kinase C and its Relevance for Dermatology. Part VIII: Skin Carcinogenesis. 23. Cutaneous Chemical Carcinogenesis. 24. Cutaneous Photocarcinogenesis. Index.

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