Principles and Practice of Image-Guided Radiation Therapy of Lung Cancer
Imaging in Medical Diagnosis and Therapy Series

This book gives a comprehensive overview on the use of image-guided radiation therapy (IGRT) in the treatment of lung cancer, covering step-by-step guidelines for clinical implementations, fundamental principles and key technical advances. It covers benefits and limitations of techniques as well as quality and safety issues related to IGRT practice.

• Addresses imaging simulation, treatment planning, verification, and delivery





• Discusses important quality assurance issues





• Describes current methods using specialized machines and technologies

Jing Cai, PhD, is an Associate Professor of Radiation Oncology at Duke University Medical Center. Joe Y. Chang, MD, PhD, is Professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. Fang-Fang Yin, PhD, is Chief of the Division of Radiation Physics, Professor of Radiation Oncology, and Director of the Medical Physics program at Duke University.

Series Preface

Preface

Editors

Contributors

Part 1 INTRODUCTION

1 Overview of IGRT

Fang-Fang Yin, Yu Yan, and Robert Timmerman

2 History and future of IGRT in lung cancer

Joe Y. Chang

Part 2 PRINCIPLES OF IGRT FOR LUNG CANCER

3 Imaging simulation for lung cancer IGRT

Daniel Low, Tinsu Pan, Ning Wen, and Carri K. Glide-Hurst

4 Treatment planning

Yan Yu, Kamila Nowak Choi, and Virginia Lockamy

5 Treatment verification and delivery

Ning Wen, Carri Glide-Hurst, Karen Chin Snyder, Mischa Hoogeman, Martina Descovich, Lei Ren, and Indrin Chetty

6 Quality assurance of IGRT

Krishni Wijesooriya, Taeho Kim, Josh Evans, and Quan Chen

Part 3 PRACTICE OF IGRT FOR LUNG CANCER 125

7 L-shaped linacs

David Hoffman, Julian Perks, Steve Goetsch, and Stanley Benedict

8 TomoTherapy

Ke Sheng

9 Robotic arm linac

Jun Yang, Andrew Cardin, Jing Feng, Xing Liang, and EnMing Wang

10 Proton therapy

Clemens Grassberger, Gregory C. Sharp, and Harald Paganetti

11 Application of IGRT for lung stereotactic body radiotherapy

Julianne M. Pollard-Larkin, Peter Balter, and Joe Y. Chang

12 Uncertainties of IGRT for lung cancer

Irina Vergalasova, Guang Li, Chris R. Kelsey, Hong Ge, Long Huang, and Jing Cai

Part 4 ADVANCES IN IGRT FOR LUNG CANCER

13 Advances in imaging simulation for lung cancer IGRT

Jing Cai, Daniel Low, Tinsu Pan, Yilin Liu, Zheng Chang, and Wei Lu

14 Advances in treatment planning

Mei Li, Ruijiang Li, and Lei Xing

15 Advances in verification and delivery techniques

Lei Ren, Martina Descovich, and Jing Wang

16 Treatment response assessment and response guided adaptive treatment

Tim Lautenschlaeger, Martha Matuszak, and Feng-Ming (Spring) Kong

17 Adaptive radiation therapy for lung cancer

Martha Matuszak, Kristy K. Brock, and Feng-Ming (Spring) Kong

18 MRI-based IGRT for lung cancer

Rojano Kashani and Lauren Henke

Index

Jing Cai, PhD, is an associate professor of Radiation Oncology at Duke University Medical Center. His research is focused on developing and clinically implementing novel image-guided radiation therapy techniques. He has published more than 50 peer-reviewed journal articles and over 130 conference abstracts. He regularly provides scientific reviews for journals and conferences, and servers as expert reviewer for grant applications. His research has received federal, charitable, and industrial funding.

Joe Y. Chang, MD, PhD, is professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. He is also Clinical Section Chief for Thoracic Radiation Oncology and Director of the Stereotactic Radiotherapy Program. He earned his PhD in cancer biology at the University of Texas MD Anderson Cancer Center, and earned his MD from Shanghai Medical College in China. He performed clinical residency at Rush-Presbyterian St. Luke Medical Center in Chicago. He is board certified in radiation oncology, and is recipient of numerous honors and is an active member of several professional organizations.

Fang-Fang Yin, PhD, is director of the DKU Medical Physics program. He has served as Chief of the Division of Radiation Physics and Professor of Radiation Oncology at Duke University since 2004. The author of more than 200 refereed publications and book chapters, Yin’s research interests include image-guided radiation therapy, informatics in cancer treatment, advanced planning and delivery techniques, and quality assurance. Yin is a Fellow and Member-at Large of the Board of Directors of the American Association of Physicists in Medicine (AAPM). He earned his Ph.D. in Medical Physics from the University of Chicago.