Role of Oxidative Stress in Chronic Diseases

This book presents recent findings on the role of oxidative stress in chronic diseases. Understanding the mechanisms by which oxidative stress act on chronic diseases enables readers to comprehend the rationale which underlies intervention in such conditions. This book gives readers a broad view in relation to an important issue related to oxidative stress, that is, genetic polymorphism. It covers the role of oxidative stress in transmissible diseases as well as non-transmissible chronic diseases. It discusses three types of non-transmissible chronic diseases: oxidative stress in metabolic diseases, in autoimmune and neurodegenerative diseases, and in cancer and cachexia. Each chapter covers a different disorder and the efficacy of interventional procedures.

Introduction. Oxidative Stress and Genetic Polymorphism. The Role of Genetic Polymorphisms in Oxidative Stress. Oxidative Stress in Transmissible Chronic Diseases. Oxidative Stress and Human Immunodeficiency Virus Type 1 (HIV‐1) Infection. Role of Oxidative Stress in Hepatitis B and C Virus. Tuberculosis. Oxidative Stress in Metabolic Diseases. Oxidative Stress in Overweight and Obesity. Dyslipidemia and Atherosclerosis. Diabetes Mellitus. Role of Oxidative Stress in Hypertension. Oxidative Stress in Metabolic Syndrome. Oxidative Stress in Alcoholic and Nonalcoholic Liver Disease. Congestive Heart Failure. Oxidative Stress in Chronic Obstructive Pulmonary Disease. Oxidative Stress in Childhood Severe Acute Malnutrition. Oxidative Stress in Skeletal Muscle Function and Dysfunction. Lead Exposure and Oxidative Stress. Common Features of Oxidative Stress and Metabolic Impairments in Human Erythrocytes and Nucleated Cells. Oxidative Stress in Autoimmune and Neurodegenerative Diseases. Oxidative Stress in Rheumatoid Arthritis: New Insights. Inflammatory Bowel Disease. Role of Mitochondria and Oxidative Stress in Parkinson’s Disease. Immunopathological Mechanisms and Oxidative Stress Damage in Multiple Sclerosis. Oxidative Stress in Stroke. Oxidative Stress in Cancer and Cachexia. Oxidative Stress in Breast Cancer. Melanoma and Oxidative Stress. Oxidative Stress in Head and Neck Cancer. Cancer Cachexia and its Relationship with Free Radicals.