Description
Sirtuins, Softcover reprint of the original 1st ed. 2016
Proteins and Cell Regulation Series, Vol. 10
Language: EnglishSubjects for Sirtuins:
Sirtuins
Publication date: 11-2016
Support: Print on demand
Publication date: 11-2016
Support: Print on demand
Sirtuins
Publication date: 07-2018
Support: Print on demand
Publication date: 07-2018
Support: Print on demand
Description
/li>Contents
/li>Comment
/li>
The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.
General introduction
Riekelt H. Houtkooper
Biochemistry and Enzymology of Sirtuins
Yue Yang and Anthony A. Sauve
NAD+ as a pharmacological tool to boost sirtuin activity
Riekelt H. Houtkooper
Protein lysine acylation: abundance, dynamics and function
Olga Pougovkina and Vincent C. J. de Boer
SIRT1 in metabolic health and disease
Marie Boutant and Carles Cantó
Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function
Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey
SIRT5 reveals novel enzymatic activities of sirtuins
Bin He and Hening Lin
Diverse roles for SIRT6 in mammalian healthspan and longevity
Bernadette M. M. Zwaans, William Giblin and David B. Lombard
Sirtuins in cancer – emerging role as modulators of metabolic reprogramming
Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis
Sirtuins as metabolic modulators of muscle plasticity
Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx
Sirtuins and aging
Carles Cantó and Riekelt Houtkooper
Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk
Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi
Sirtuin activation by small molecules
Hassina Massudi, Lindsay E. Wu, and David A. Sinclair
Future perspective
Brian Kennedy
Index
Key leaders in the field of sirtuin biology share their expertise
Covers a wide variety of physiological processes controlled by sirtuin proteins
Offers new insights into how sirtuin proteins can be targeted to treat age-related diseases
Includes supplementary material: sn.pub/extras
© 2024 LAVOISIER S.A.S.
These books may interest you
Metabolic Control 210.99 €