Structural Biology in Immunology Structure/Function of Novel Molecules of Immunologic Importance
Coordonnateurs : Putterman Chaim, Cowburn David, Almo Steven
Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease.
1. Organization of Immunological Synapses and Kinapses 2. Principles of Protein Recognition by Small T-Cell Adhesion Proteins and Costimulatory Receptors 3. Synthetic Antibody Engineering: Concepts and Applications 4. Natural Killer Cell Receptor 5. Structure-Function in Antibodies to Double-Stranded DNA 6. The Role of the Constant Region in Antibody-Antigen Interactions: Redefining the Modular Model of Immunoglobulin Structure
Dr. David Cowburn is Professor in the Departments of Biochemistry and Physiology & Biophysics at the Albert Einstein College Of Medicine, David Cowburn's research centers on the application of structural biology, and particularly, nuclear magnetic resonance (NMR), to biological problems. He was a faculty member at Rockefeller University 1973-2000, and served as the start-up President and CEO of the New York Structural Biology Center, 2000-2010. http://cowburnlab.org/DavidCowburnFullBio.pdf.
Dr. Steven Almo is a Professor in the Departments of Biochemistry and Physiology and Biophysics. Dr. Almo is a world renowned expert in structural biology and crystallography. He directs Einstein research as part of the NIGMS’s Protein Structure Initiative (PSI), a decade-long federal, university and industry effort aimed at dramatically reducing the costs and lessening the time it takes to determine a three-dimensional protein structure from its DNA sequence. He is Director of Structural Proteomics, New York Structural Biology Center, November 2006-present And Director, Albert Einstein Macromolecular Therapeutic Development Facility 2007-present. He is member of the American Society for Cell Biology and American Crystallographic Association
- Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules
- Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship
- Features a collaborative editorial effort, involving clinical immunologists and structural biologists
- Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology
- Gives interested parties a bridge to learn about computer modeling and structure based design principles
Date de parution : 05-2018
Ouvrage de 186 p.
15x22.8 cm
Thème de Structural Biology in Immunology :
Mots-clés :
Actin; Activation; Adhesion molecule; Allosteric antibody model; ALW; Antibody constant region; Antibody-antigen interactions; Anti-dsDNA antibodies; Cell-cell recognition; Cortex; Costimulatory receptor; Crystallography; Double-stranded DNA; Ectosomes; Exocytosis; Exosomes; Extracellular vesicles; Immunoglobulin fine specificity; Intramolecular signaling; Isotype-switching; Kinapse; KIR; Ly49; MHC; Modular antibody model; Monoclonal antibodies; Natural killer cell receptor; NKG2D; Nuclear magnetic resonance; Phage display; Phase separation; Protein engineering; Receptor signaling; Signaling; SLE; Structure; Synapse; Synthetic antibodies; T cell; Virus
