Th17 Cells: Role in inflammation & autoimmune disease (Progress in inflammation research)

With the recent definition of the Th17 cell subset, a new paradigm in innate and adaptive immunity has been established. This book describes the function of the Th17 cell subset and its prevalent role in many inflammatory and autoimmune diseases. The mechanism by which this T cell subset is generated and maintained shows specific differences between mice and man which are reviewed. One characteristic of Th17 cells is to secrete specific and unique cytokines such as IL-17A, IL-17F and IL-22, their functions are described in detail. These cytokines have acquired a prevalent role in many pathological conditions in animal models and in humans. Targeting these cytokines as well as the generation of Th17 cells may open new ways to treat many autoimmune diseases. The role of Th17 in infectious conditions is also addressed.

IL-22 and IL-17 common and different properties.- Other sources of IL-17: iNKT cells.- Contributions of IL-22 to Th17 responses: Repairing and protecting peripheral tissues.- Retinoic acid in mucosal immune-regulation.- IL-2. another promoter of allergy.- Critical role of IL-17 in experimental arthritis.- Dual role of IL-17 in allergic asthma.- Contribution of IL-17 to the pulmonary inflammatory response.- The role of IL-17 in experimental autoimmune myocarditis.- Th17 cells in organ transplantation.- Is IL-17 required to control tuberculosis?- IL-17 and mucosal host defense.- IL-23 orchestrates the switch from tumor immune surveillance to tumor promoting inflammation.- IL-17 and Th17 cells in rheumatoid arthritis.- Targeting Th17 cells in CNS immune pathology.- IL-17 cytokines in asthma.- IL-17/2. potential targets for Crohns disease.- IL-17A and Th17 cells as therapeutic targets for autoimmune diseases

From the reviews:'This very interesting volume contains 18 reviews grouped in five chapters and presents the accumulated knowledge related to the IL-17 cytokines, a novel family of cytokines that defines a new effector T cell, the Th17 cell, and extends the Th1-Th2 paradigm. ... This multi-authors volume is an exciting and rewarding reading for scientists and medical doctors exploring novel mechanisms of inflammation and therapy.' (Mihaela Trif, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)