The Frontal Lobes
Handbook of Clinical Neurology Series

The Frontal Lobes, Volume 163, updates readers on the latest thinking on the structure and function of the human frontal lobe. Sections address methodology, anatomy, physiology and pharmacology, function, development, aging and disorders, and rehabilitation. Patients with focal lesions in the frontal lobes have long been studied to reveal the organization and function of the frontal lobes. Over the last two decades, studies of patients with neurodegenerative diseases and developmental disorders have increased, with new findings discussed in this volume. In addition, the book includes discussions on genetics and molecular biology, optogenetics, high-resolution structural and functional neuroimaging and electrophysiology, and more.

Lastly, new knowledge on the biology, structure and function of the frontal lobes, new treatment targets for pharmacology, non-invasive brain stimulation, and cognitive/social remediation are presented. The last section covers new efforts that will hopefully lead to better outcomes in patients with frontal lobe disorders.

Section I. History 1. The prefrontal cortex in the neurology clinic

Section II. Methods 2. The functions of the frontal lobes: Evidence from patients with focal brain damage 3. EEG/ECoG 4. Functional imaging 5. Transcranial magnetic stimulation: Neurophysiological and clinical applications

Section III. Anatomy, Physiology and Pharmacology 6. The anatomy of the human frontal lobe 7. Dopamine and the motivation of cognitive control

Section IV. Function of the Frontal Lobes 8. Frontal lobe syndromes 9. Hierarchical cognitive control and the frontal lobes 10. Hemispheric asymmetry in the prefrontal cortex for complex cognition 11. Executive functions 12. The lateral prefrontal cortex and human long-term memory 13. From ideas to action: the prefrontal-premotor connections that shape motor behavior 14. Emotion regulation across the life span 15. Reward 16. Moral conduct and social behavior 17. Computational models 18. Control networks of the frontal lobes

Section V. Development, Aging and Disorders 19. Development of the frontal lobe 20. Aging of the frontal lobe 21. Neurodegenerative disorders of the human frontal lobes 22. Traumatic brain injury and frontal lobe plasticity

Section VI. Rehabilitation 23. Strengthening goal-directed functioning after traumatic brain injury 24. Experimental social training methods 25. Plasticity and recovery of function

• Provides an overview of the structure, function, disorder and rehabilitation of the frontal lobes
• Addresses a wide variety of methodologies – from genetics and molecular biology, to optogenetics and hi-res fMRI, and more
• Contains content of interest to advanced students, junior researchers and clinicians getting involved in research
• Features the input of leaders in neuroanatomical research from around the globe – the broadest, most expert coverage available