The Opioid System as the Interface between the Brain’s Cognitive and Motivational Systems

The Opioid System as the Brain?s Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain?s cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain?s cognitive system, the Brain?s motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.

1. Potential roles for opioid receptors in motivation and major depressive disorder Charlotte K. Callaghan, Jennifer Rouine and Shane M. O'Mara 2. Opioid modulation of depression: A focus on imaging studies Jennifer Rouine, Charlotte K. Callaghan and Shane M. O’Mara 3. Modulation of the central opioid system as an antidepressant target in rodent models Kelly L. McHugh and John P. Kelly 4. Stress-induced modulation of pain: Role of the endogenous opioid system Mehnaz Ferdousi and David P. Finn 5. Opioid modulation of cognitive impairment in depression Moriah L. Jacobson, Hildegard A. Wulf, Caroline A. Browne and Irwin Lucki 6. Frontal cortex dysfunction as a target for remediation in opiate use disorder: Role in cognitive dysfunction and disordered reward systems Dominic Roberts, Andrew Wolfarth, Connie Sanchez and Alan L. Pehrson

• Contains contributions from both academia and industry to maximize the cross-fertilization of differing perspectives on opioid system function in health and disease
• Studies the opioid system as the interface between the brain’s cognitive and motivational systems