Tissue Engineering and Regenerative Medicine
A Nano Approach

Through the integration of strategies from life science, engineering, and clinical medicine, tissue engineering and regenerative medicine hold the promise of new solutions to current health challenges. This rapidly developing field requires continual updates to the state-of-the-art knowledge in all of the aforementioned sciences. Tissue Engineering and Regenerative Medicine: A Nano Approach provides a compilation of the important aspects of tissue engineering and regenerative medicine, including dentistry, from fundamental principles to current advances and future trends.

Written by internationally renowned scientists, engineers, and clinicians, the chapters cover the following areas:

• Nanobiomaterials and scaffolds?including nanocomposites and electrospun nanofibers
• Tissue mechanics
• Stem cells and nanobiomaterials
• Oral and cranial implants and regeneration of bone
• Cartilage tissue engineering
• Controlled release?DNA, RNA, and protein delivery
• Animal science and clinical medicine

The editors designed this textbook with a distinctive theme focusing on the utilization of nanotechnology, biomaterials science in tissue engineering, and regenerative medicine with the inclusion of important clinical aspects. In addition to injured veterans and other individuals, increased life expectancy in the industrialized world is creating a growing population that will require regenerative medicine, producing greater pressure to develop procedures and treatments to improve quality of life. This book bridges the gap between nanotechnology and tissue engineering and regenerative medicine, facilitating the merger of these two fields and the important transition from laboratory discoveries to clinical applications.

Biostable Composite Biomaterials in Medical Applications. Bioceramic and Biopolymer Nanocomposite Materials for Use in Orthopedic Applications. Tailoring of Bioactive Glasses. Bioactive Ceramic Coatings for Metallic Implants. Induction of Bone Formation by Calcium Phosphate-Based Biomimetic Macroporous Constructs. Bioinspired Titanium Implants: The Concavity—The Shape of Life. Bioactive Surface Modifications for Dental and Orthopedic Implants. Oral Implants: Biological Background and Current Concepts in Peri-Implantitis Treatment. Soft Tissue Attachment on Implant Surface. Surface Chemical Determination of the Placement, Growth, and Differentiation of Cells for Drug Screening, Toxin Detection, and Lab-on-a-Chip Applications. Electrospun Nanofibers as Next-Generation Bioactive Tissue Scaffolds. Mechanics of Fiber-Reinforced Scaffolds and Tissues Formed from Organized Electrospun Assemblies. Regulation of Stem Cell Behavior Using Nanobiomaterials. Biomaterials and Their Use in Craniofacial Surgery. Nanobiomaterials for Bone Tissue Engineering. Stem Cells, Growth Factors, and Biomaterials in Bone Surgery. Nanomaterials for Cartilage Regeneration. Cartilage Tissue Engineering: Advances in Stem Cell-Based Approaches. Stem Cells and Nanobiomaterials for Cardiac Tissue Regeneration. Nanotechnology for Engineering Cellular Microenvironment and Gene Delivery. Nanobiomaterial-Based Short Interfering RNA Delivery Systems. Sugar–Glass Nanoparticles for Protein Delivery. Clinical Relevance of Tissue Engineering. Future Perspectives of Biomaterials and Stem Cells in Regenerative Medicine. Index.

Murugan Ramalingam is an associate professor and scientist ‘G’ at the Centre for Stem Cell Research (CSCR), Department of Biotechnology, Government of India, Christian Medical College Bagayam Campus, Vellore, Tamil Nadu, India. He is also an adjunct associate professor at the Tohoku University, Sendai, Miyagi, Japan. Dr. Ramalingam’s current research interests focus on the development of multiphase biomaterials, through conventional to nanotechnology to biomimetic approaches, cell patterning, stem cell differentiation, and tissue engineering. He is the author of more than 125 publications, including peer-reviewed journal papers, conference proceedings, book chapters, authored books, edited books, and patents relevant to biomaterials and tissue engineering. He serves on the editorial boards of multiple biomaterials- and tissue engineering-related journals.

Pekka Vallittu is a full professor of biomaterials science in the Faculty of Medicine, University of Turku, Finland, and works as the dean of the Institute of Dentistry and the director of the Turku Clinical Biomaterials Centre. He is also an honorary professor at the University of Hong Kong, Pokfulam. Professor Vallittu’s research activity on fiber-reinforced composites started from his hobby of model aircraft and has lasted for more than 25 years. His first applications for fiber-reinforced composites were in dentistry, followed by active research to utilize fiber-reinforced composites as biomimetic materials, also in medicine. Professor Vallittu has more than 300 original research papers, 500 other papers and abstracts, and 140 granted international patents based on 17 innovations. He has been awarded a Distinguished Scientist Award in Prosthodontics and Implant Research by the International Association of Dental Research.

Ugo Ripamontiis a professor and the director of the Bone Research Laboratory, a research unit of the South African