Description
Twin and Family Studies of Epigenetics
Translational Epigenetics Series
Coordinators: Li Shuai, Hopper John
Director of collection: O Tollefsbol Trygve
Language: EnglishKeywords
Twin studies; twin study; epigenetic twin study; epigenetic twin studies; family study design; family studies; epigenetics and family studies; epigenetics and family study; Epigenetics and measurement; Developmental epigenetics; development and disease; nature vs; nurture; epigenetics and aging; twin studies; epigenetic mechanisms and mental health; DNA methylation; breast cancer; pediatric dental health; epigenetics and diabetes; epigenetics and obesity; epigenetics and cardiovascular disease; DNA methylation and blood pressure; epigenetics and lifestyle; imaging epigenetics; radiogenomics; exposure-specific DNA Methylation; epigenetic effects; epigenomics
374 p. · 19x23.4 cm · Paperback
Description
/li>Contents
/li>Biography
/li>Comment
/li>
Twin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more.
Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects.
ART 1 Introduction 1. Value of twin and family study designs for epigenetic research 2. Evaluation and measurement of epigenetic modifications in population-based studies
PART 2 Human health applications 3. Discordant monozygotic twin studies of epigenetic mechanisms in mental health 4. DNA methylation and breast cancer risk: value of twin and family studies 5. Twin and family studies on epigenetics and oral health 6. Twin and family epigenetic studies of type 2 diabetes 7. Twin and family studies on epigenetics and obesity 8. DNA methylation and blood pressure in Chinese adult twins 9. Twin and family studies on epigenetics of autoimmune diseases 10. Twin studies on the epigenetics of selected neurological disorders and carotid artery disease 11. Disease-discordant twin studies of epigenetics and cancer 12. Sex differences in epigenetic profiles: The value of twin studies
PART 3 Emerging approach 13. Combining twin-family designs with measured genetic variants to study the causes of epigenetic variation 14. Imaging epigenetics and the radiogenomics 15. DNA methylation changes specific to environmental exposures: The strengths of twin studies using cigarette smoking as an example 16. Time trends in epigenetic signatures and population health risks 17. Ambient air pollution and human epigenetic modifications
Professor John Hopper, AM, was one of the nine inaugural Australia Fellows awarded by NHMRC in 2007 and is currently a NHMRC Senior Principal Research Fellow. He is a Professorial Fellow with a PhD in Mathematical Statistics, and is currently Director (Research) of the Centre for Epidemiology and Biostatistics in the School of Population Global Health at The University of Melbourne. He has published more than 700 papers, specializing in the statistical methodology and its application for analyzing twin and family data, and addressing the genetic and environmental aetiology of diseases and health. He is principal or co-investigator on a number of case-control-family studies across a range of diseases and conditions, particularly breast cancer and colorectal cancer (both funded by the National Institutes of Health (USA)), prostate cancer, melanoma, childhood cancer and asthma. He is a co-investigator on several cohort studies, including Health 2020 and long term follow-up of the 1968 Tasmanian Asthma Study. Professor Hopper has been Director of the Australian Twin Registry (Now is Twins Research Australia) since 1990 and has been awarded a NHMRC CRE grant in Twin Research in 2014.
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor wi
- Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties
- Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders
- Features chapter contributions from a wide range of international researchers in the field
These books may interest you
Epigenetics in Human Disease 170.55 €