Description
Vascularization for Tissue Engineering and Regenerative Medicine, 1st ed. 2021
Tissue Engineering and Regeneration Series
Language: EnglishSubjects for Vascularization for Tissue Engineering and Regenerative...:
565 p. · 15.5x23.5 cm · Hardback
Description
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Wolfgang Holnthoner obtained both his M.Sc. in microbiology and genetics and his Ph.D. in molecular biology from the University of Vienna, Austria. For more than 20 years he has been working on endothelial cells, both from blood and lymphatic vessel origin. After his postdoctoral training with Kari Alitalo at the University of Helsinki, Finland, where he has been exploring signal transduction in lymphatic endothelial cells, he started at the Ludwig-Boltzmann-Institute for Experimental and Clinical Traumatology to work on strategies for pre-vascularization of tissue-engineered constructs. He is interested in the basic functions of endothelial cells in vasculogenesis, angiogenesis, and lymphangiogenesis. His group’s primary focus is the regeneration/engineering of microvascular structures. To this aim, he employs co-culturing primary endothelial cells with supporting cell types to achieve functional oxygen and nutrient support of tissues. Dr. Holnthoner uses the physiological and biocompatible scaffold fibrin to provide cells the necessary 3D environment for microvascularization. In addition, his research involves the integration of lymphatic vessels, since they are the ones that transport the interstitial fluid in tissues back to the blood circulation, and without them, human life would be inconceivable. Moreover, he strives to explore the emerging role of extracellular vesicles (EV) in intercellular communication. These efforts contribute to the development of therapies aimed for regeneration of diseased tissues.
Andrea Banfi directs the Cell and Gene Therapy research group at the University Hospital of Basel, Switzerland. He previously worked in Genova (Italy) and Stanford (CA, USA). His research focuses on: 1) understanding the basic principles governing the growth of blood vessels, particularly the molecular crosstalk between endothelium, mural cells and inflammatory monocytes, in
Discusses both fundamental and cutting-edge research
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Written by international experts in the field