Zika Virus Impact, Diagnosis, Control, and Models
Volume 2: The Neuroscience of Zika Virus

Coordinators: R Martin Colin, Hollins-Martin Caroline, Preedy Victor R, Rajendram Rajkumar

Language: English
Cover of the book Zika Virus Impact, Diagnosis, Control, and Models

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Zika Virus Impact, Diagnosis, Control, and Models: Volume Two: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. The book also details the neuroscience of Guillain-Barré syndrome, its effects and neuromuscular rehabilitation. It is designed to help readers better understand detection, therapies for Zika virus, preventative vaccines, diagnosis and associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

Section 1 – Methods, Biomarkers, and Diagnosis1. Imaging Zika virus infection2. Use of CRISPR: applications to flaviviruses3. Methods of investigating neurotoxicity of larvicides: applications of systems biology4. Methods for the detection of Zika virus infectivity

Section 2 – Vector Control, Vaccines, Pharmacology 5. Vector control and Zika virus: a focus on mosquitoes6. Vector control: a focus on rural household containers: applications to Zika virus7. Zika virus Vaccines: an overview8. Novel treatment with 2,8-bis(trifluoromethyl)quinoline analogs in Zika infection in vitro9. Zika virus use of human neutralizing antibody in microcephaly prevention: a modelling system10. Policies on Zika virus Control

Section 3 – Novel and Non-Pharmacologic Therapies11. Role of the pediatric neurologist in treating Zika virus syndrome12. 25-Hydroxycholesterol usage in Zika Virus Infection13. Screening and inhibition of the flavivirus NS2B-NS3 protease: application to zika virus14. Gene silencing and applications to zika virus15. Screening phytochemicals that react against Zika virus

Section 4 – Models and Modelling16. Guinea pig model of Zika virus: features and applications17. Rat model of Zika virus: features and applications18. Mouse model of Zika virus: features and applications19. Modelling Zika virus in the USA20. Modelling Zika virus infection in laboratory animals: impact on neurological systems

Section 5 – Neuroscience of Guillain-Barré Syndrome21. Severe Guillain-Barré Syndrome22. Plasmablasts, plasma and neurotoxic antibodies in Guillain-Barré syndrome23. Oxidative stress in Guillain-Barré Syndrome and linkage with neurology24. Neuromuscular effects and rehabilitation in Guillain-Barré syndrome25. Post-infectious demyelinating diseases: Guillain-Barré syndrome and beyond

Section 6 – Neuroscience of Microcephaly26. Microcephaly and developmental delays27. Congenital microcephaly: features and risk factors28. Microcephaly in fetal alcohol syndrome29. Microcephaly in genetic disorders: the case of MFSD2A and hypomyelination30. Folate metabolism, 5,10-methenyltetrahydrofolate synthetase and microcephaly

Section 7 – International Aspects31. Zika Virus in Honduras32. Zika Virus in Uganda33. Zika Virus in Jamaica34. Zika virus in Mozambique35. Zika virus in Brazil

Section 8 – Case Reports36. Case reports: Zika and Chikungunya virus infection37. Case reports: Zika virus neuroretinitis38. Case reports: Zika virus infection in Singapore39. Case reports: Coinfection with Zika virus and dengue-2 viruses40. Case report: Guillain-Barré and Zika virus infection

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collabo
  • Provides a broad range of topics related to the neuroscience of Zika, including its diagnosis, vaccines and therapy
  • Contains chapter abstracts, key facts, a dictionary of terms and summary points to aid in understanding
  • Discusses novel and non-pharmacological therapies, Guillain-Barré Syndrome and vaccine development
  • Features chapters on rat, mouse, and guinea pig models of Zika and case reports of Zika co-infection with chikungunya, dengue-2 and Guillain-Barré
  • Includes coverage of microcephaly and developmental delays and examines Zika outbreaks in Brazil, Honduras, Uganda, Jamaica and Mozambique