Description
In Vivo Models to Study Angiogenesis
Author: Ribatti Domenico
Language: EnglishSubjects for In Vivo Models to Study Angiogenesis:
Keywords
Angiogenesis; Antiangiogenesis; Chamber; Chemoinvasion; Chorioallantoic membrane; Cranial window chamber; Disk system; Dorsal air sac; Ear chamber; Endothelial cells; Fibroblasts; Granulation tissue; Hamster cheek pouch; Matrigel; Mice; Morpholino; Mouse corneal assay; Orthotopic model; Polyvinyl alcohol; Rabbit corneal assay; Rat; Rat corneal assay; Rat mesentery assay; Skinfold chamber; Sponge; Transgenic mouse models; Tumor angiogenesis; Tumor growth; Zebrafish
Support: Print on demand
Description
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In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available.
Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling.
The corneal micropocket assay
The zebrafish embryo
The sponge implant method
The Matrigen implant assay
In vivo gene transfer with AAV vectors
In vivo tumor models
Researchers and postgraduates working on angiogenesis, tissue engineering, oncology; particularly early-career and PhD-level researchers
He has published many books with both Elsevier and Springe
- Provides information on the most common assays to study angiogenesis in vivo
- Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development
- Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant