ADP-Ribosylation: Metabolic Effects and Regulatory Functions, 1994
Developments in Molecular and Cellular Biochemistry Series, Vol. 12

Considering the current interest in cellular regulation and intracellular signalling systems, it is surprising that the contribution of ADP-ribosylation reactions to the modulation of a variety of specific cell processes, in parallel with other post-translational modifications such as phosphorylation, has not been generally recognized. While it is not feasible to cover all aspects of ADP-ribosylation, the thirty-one articles contained in this volume provide a valuable overview of recent progress in the field within the context of cell control mechanisms. For the convenience of the reader, the various topics have been grouped into several sections: (a) poly(ADP-ribosyl)ation; (b) mono-ADP-ribosylation; (c) toxin mono-ADP-ribosylation; (d) inhibitors and activators; (e) protein modification with ADP-ribose and its analogues; and (f) non-modification forms of ADP-ribose. The contents of the individual chapters reflect the ideas of the contributors, many of whom have spent their careers attempting to resolve the biological functions of ADP-ribosylation. We hope that this publication will serve as a useful reference for those investigators that are new to the area as well as those who are actively studying ADP-ribosylation.

I: Historical perspective.- Poly(ADP-ribose): Historical perspective.- II: Poly(ADP-ribosyl)ation A. Structure and enzymology of poly(ADP-ribose) polymerase.- Structure and function of poly(ADP-ribose) polymerase.- Poly(ADP-ribose) polymerase: Structural conservation among different classes of animals and its implications.- Enzymology of ADP-ribose polymer synthesis.- Interaction of poly(ADP-ribose)polymerase with DNA polymerase ?.- Poly(ADP-ribose) catabolism in mammalian cells.- Histone shuttling by poly ADP-ribosylation.- Growth-phase-dependent response to DNA damage in poly(ADP-ribose) polymerase deficient cell lines: basis for a new hypothesis describing the role of poly(ADP-ribose) polymerase in DNA replication and repair.- The function of poly (ADP-ribosylation) in DNA breakage and rejoining.- Poly(ADP-ribose) polymerase gene on chromosome 1q: Early role in differentiation linked replication; gene on human chromosome 13q: Marker of carcinogenesis.- Poly(ADP-ribose) polymerase activity in intact or permeabilized leukocytes from mammalian species of different longevity.- ADP-ribosylation and gene expression.- Transcriptional regulation and autoregulation of the human gene for ADP-ribosyltransferase.- III: Mono(ADP-ribosylation).- Vertebrate mono-ADP-ribosyltransferases.- Target protein for eucaryotic arginine-specific ADP-ribosyltransferase.- ADP-ribosylarginine hydrolases.- Reversible ADP-ribosylation as a mechanism of enzyme regulation in procaryotes.- Cellular ADP-ribosylation of Elongation Factor 2.- Characterization of botulinum C3-catalyzed ADP- ribosylation of rho proteins and identification of mammalian C3-like ADP-ribosyltransferase.- ADP-rybosylation of the molecular chaperone GRP78/BiP.- IV: Toxin mono-ADP-ribosylation.- Diphtheria toxin-relatedcytokine fusion proteins: Elongation factor 2 as a target for the threatment of neoplastic disease.- ADP-ribosylation factors: a family of ?20-kDa guanine nucleotide-binding proteins that activate cholera toxin.- Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins.- Common structure of the catalytic sites of mammalian and bacterial toxin ADP- ribosyltransferases.- V: Inhibitors and activators of ADP-ribosylation.- Inhibitors and activators of ADP-ribosylation reactions.- VI: Derivation of proteins with ADP-ribose, NAD and their analogues.- Nitric oxide and NAD-dependent protein modification.- Glycation of proteins by ADP-ribose.- DeoxyNAD and deoxyADP-ribosylation of proteins.- Enzymatic and nonenzymatic ADP-ribosylation of cysteine.- VII: Cyclic ADP-ribose, NAD hydrologis and ADP-ribose synthesis.- Cyclic ADP-ribose: A calcium mobilizing metabolite of NAD+.- NAD glycohydrolases: A possible function in calcium homeostasis.- NAD hydrolysis: Chemical and enzymatic mechanisms.- Index to Volume 138.